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  4. Recombinant Saccharomyces cerevisiae ATP-dependent DNA helicase MPH1 (MPH1), partial

Recombinant Saccharomyces cerevisiae ATP-dependent DNA helicase MPH1 (MPH1), partial

  • 中文名稱：
    釀酒酵母MPH1重組蛋白
  • 貨號：
    CSB-YP334739SVG
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母MPH1重組蛋白
  • 貨號：
    CSB-EP334739SVG
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母MPH1重組蛋白
  • 貨號：
    CSB-EP334739SVG-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母MPH1重組蛋白
  • 貨號：
    CSB-BP334739SVG
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母MPH1重組蛋白
  • 貨號：
    CSB-MP334739SVG
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MPH1
  • Uniprot No.：
  • 別名：
    MPH1; YIR002C; YIB2C; ATP-dependent DNA helicase MPH1; EC 3.6.4.12; FANCM-like protein 1; Mutator phenotype protein 1
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Prevents crossovers between ectopic sequences by removing substrates for MUS81-MMS4 or RAD1-RAD10 cleavage. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable). Binds to flap-structured DNA but not to non-flap nicked DNA, and participates in Okazaki fragment processing by stimulating the endonuclease activities of FEN1 and DNA2. Involved in recombination donor preference during mating-type switching via interaction with FKH1.
  • 基因功能參考文獻：
    1. Mutator phenotype of MPH1 overexpression suggests a novel gain-of-function mechanism. DEAH-box function was required for hypermutation, mutagenesis by MPH1 overexpression was independent of translesion synthesis, but was suppressed by overexpression of RAD27. PMID: 27585847
    2. Mph1regulates the REC-mediated choice between gene conversion and break-induced replication (BIR). Double deletion of Sgs1 and Mph1 abolishes the REC-mediated lag observed during the repair of large gaps and BIR substrates. PMID: 27075725
    3. Mte1 functions with Mph1 and the associated MHF complex in replication fork repair PMID: 26966246
    4. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres PMID: 26966248
    5. Data support the hypothesis that Mph1 is the main helicase responsible for template switching during break-induced replication. PMID: 24496010
    6. Mph1 does not affect the overall efficiency of gap repair, and its loss alters the CO-NCO by promoting synthesis-dependent-strand-annealing at the expense of HJ-containing intermediates. PMID: 23516370
    7. Mph1 is a double-edge sword at the telomere, it prevents NHEJ, but promotes senescence in cells with dysfunctional telomeres by increasing the levels of ssDNA PMID: 22848695
    8. Characterization of Mph1 helicase activity with a variety of DNA substrates, focusing on its action on junction structures containing three or four DNA strands. PMID: 22090425
    9. These biochemical results not only provide validation for a role of Mph1 in the repair of damaged replication forks, but they also offer mechanistic insights as to its ability to efficiently disrupt the D-loop intermediate. PMID: 21880555
    10. Mph1 has an additional function in recombination besides its previously described ability to disrupt D-loops; Mph1 promotes D-loop formation. PMID: 20951099
    11. This study describes a synthetic growth defect of an mph1 deletion if combined with an srs2 deletion that can result-depending on the genetic background-in synthetic lethality. PMID: 19918932
    12. the MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase PMID: 15634678
    13. Mph1p promotes gross chromosomal rearrangement formation by partially suppressing homologous recombination, likely through its interaction with replication protein A. PMID: 18591428
    14. a new role of Mph1 in promoting the noncrossover repair of DNA double-strand breaks PMID: 19136626
    15. These findings suggest that Mph1 plays an important, although not essential, role in processing of Okazaki fragments by facilitating the formation of ligatable nicks. PMID: 19181670

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily, FANCM sub-subfamily
  • 數據庫鏈接：

    KEGG: sce:YIR002C

    STRING: 4932.YIR002C



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