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  4. Recombinant Rat cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial

Recombinant Rat cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial

  • 中文名稱：
    大鼠Pde5a重組蛋白
  • 貨號：
    CSB-YP523851RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pde5a重組蛋白
  • 貨號：
    CSB-EP523851RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pde5a重組蛋白
  • 貨號：
    CSB-EP523851RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pde5a重組蛋白
  • 貨號：
    CSB-BP523851RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pde5a重組蛋白
  • 貨號：
    CSB-MP523851RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pde5a; Pde5; cGMP-specific 3',5'-cyclic phosphodiesterase; EC 3.1.4.35; cGMP-binding cGMP-specific phosphodiesterase; CGB-PDE
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
  • 基因功能參考文獻：
    1. Our data showed a significant and previously undocumented upregulation of PDE5 in both rat and human BPH. PMID: 26657792
    2. The effects of vasodilation on plasma volume expansionhemodilution, and PDE5A expression via the renin-angiotensin-aldosterone system are reported. PMID: 24068049
    3. The phosphodiesterase 5A inhibitors decrease NHE-1 phosphorylation and activity through a mechanism that involves PP2A activation. PMID: 21063091
    4. mRNA transcript and protein levels of PDE5 in the main and first branch of the pulmonary arteries are increased by chronic hypoxia. PMID: 12466227
    5. PDE-5 is constitutively present in the rat uterine wall. There was no observed change in the PDE-5 protein expression throughout pregnancy. PMID: 14749671
    6. Kinetics of rat cellular nitric oxide/cGMP/phosphodiesterase-5 pathway PMID: 15075333
    7. normal rat pregnancy leads to in vivo and in vitro renal resistance to atrial natriuretic peptide, in association with heightened activity of the cGMP-specific PDE5 PMID: 15100365
    8. PDE5A may also play a critical role in the growth promoting effects of Angiotensin II PMID: 15623434
    9. Increased PDE-5 expression is involved in the decreased vascular response to nitric oxide in cirrhotic livers PMID: 16545481
    10. PDE5 controls the soluble cyclic GMP pool in cardiac myocytes. PMID: 16651469
    11. PDE5 activity limits action potential propagation in neurohypophysial axons. PMID: 17690141
    12. Phosphodiesterase 5A expression confirms the activity targeted inhibition by sildenafil in cardiomyocytes and hypertrophy modulation. PMID: 18790048
    13. PDE5 expression was not under direct androgen regulation. PMID: 19338748

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  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 數據庫鏈接：


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