在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Vitamin K-dependent protein C (Proc)

  • 中文名稱:
    大鼠Proc重組蛋白
  • 貨號(hào):
    CSB-YP018742RA
  • 規(guī)格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Proc; Vitamin K-dependent protein C; EC 3.4.21.69; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    Full Length of Mature Protein
  • 來(lái)源:
    Yeast
  • 分子量:
    49.3 kDa
  • 表達(dá)區(qū)域:
    42-461aa
  • 氨基酸序列
    ANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCDSPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCRCAPGYELADDHMHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSPKL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function.
  • 基因功能參考文獻(xiàn):
    1. Vascular endothelial damage in Lipopolysaccharide-induced sepsis model is attenuated by activated protein C. PMID: 25813362
    2. APC treatment significantly improves pial microcirculation by reducing leukocyte adhesion and increasing functional capillary density PMID: 22426124
    3. mutated Protein C did not appear to alter the levels of NFkB or fibrinogen in our model of hemorrhagic shock and resuscitation. PMID: 21962741
    4. Xuebijing could upregulate EPCR and PAR1 mRNA and protein expression of rat aortic endothelial cells after LPS challenge. PMID: 19278590
    5. activated protein C induces the reduction of the nuclear level of NF-kappaB p65 in hippocampal neurons at glutamate-induced excitotoxicity via binding to EPCR and subsequent PAR-1 activation and signaling PMID: 19931359
    6. APC reduces stress-induced gastric mucosal injury by inhibiting the decrease in gastric mucosal blood flow through attenuation of the activated neutrophil-induced endothelial cell injury via inhibition of TNF-alpha production. PMID: 14995995
    7. Low levels of protein C (PC) predict outcome as early as 10 hr after insult in a rat polymicrobial sepsis model and are associated with suppression of PC mRNA. PMID: 16522789
    8. Activated protein C is a promising therapeutic option for hepatic ischaemia-reperfusion injury. PMID: 18507760
    9. APC at low concentrations, activating PAR1, prevents the death of hippocampal and cortical neurons under conditions of glutamate excitotoxicity. PMID: 18620539
    10. NO generated immediately after isoflurane exposure triggers downstream activation of NF-kappaB, resulting in subsequent upregulation of iNOS expression and NO synthesis that mediate APC-induced delayed cardioprotection PMID: 18708911
    11. although PAR-1 agonism is solely responsible for APC-mediated improvement in systemic hemodynamics, both functions of APC play distinct roles in attenuating the response to injury in the kidney PMID: 19092124

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted. Golgi apparatus. Endoplasmic reticulum.
  • 蛋白家族:
    Peptidase S1 family
  • 組織特異性:
    Plasma; synthesized in the liver.
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 亚洲欧美人成网站在线观看看| 99精品国产在热久久| 免费午夜无码片在线观看影院| 无码国产精品高清免费| 欧美丰满美乳xxⅹ高潮www| 性xxxx18免费观看视频| √天堂中文www官网在线| 免费全部高h视频无码| 无码纯肉动漫在线观看| 影视先锋男人无码在线| 日本乱偷人妻中文字幕在线| 国产精品日日做人人爱| 手机看黄av免费网址| 国产在线视频主播区| 夫妇交换性三中文字幕| 欧美日韩一区二区三区自拍| 欧洲无码精品a码无人区| 无码人妻一区二区三区四区av| 久久婷婷五月综合色国产| 亚洲午夜性猛春交xxxx| 国产成人免费无庶挡视频| 中文字幕制服丝袜人妻动态图 | 国产无遮挡裸体免费视频在线观看 | 成人18禁深夜福利网站app免费| 免费精品国产人妻国语| 中文字幕av久久激情亚洲精品 | 国产成人愉拍精品| 天天摸天天碰天天添| 日韩精品一区二区三区vr| 97国产在线看片免费人成视频| 国产成人精品日本亚洲网站| 成人性生交大片免费看96| 亚洲 自拍 色综合图区av| 真实国产熟睡乱子伦视频| 亚洲精品美女久久7777777| 精品麻豆一区二区三区乱码| 白嫩少妇bbw撒尿视频| 欧美人与动另类xxxx| 亚洲国产美女精品久久久久∴ | 狠狠色色综合站| 亚洲日韩久久综合中文字幕|