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  4. Recombinant Rat Urea transporter 1 (Slc14a1), partial

Recombinant Rat Urea transporter 1 (Slc14a1), partial

  • 中文名稱：
    大鼠Slc14a1重組蛋白
  • 貨號：
    CSB-YP021396RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Slc14a1重組蛋白
  • 貨號：
    CSB-EP021396RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Slc14a1重組蛋白
  • 貨號：
    CSB-EP021396RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Slc14a1重組蛋白
  • 貨號：
    CSB-BP021396RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Slc14a1重組蛋白
  • 貨號：
    CSB-MP021396RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc14a1
  • Uniprot No.：
  • 別名：
    Slc14a1; UT11; UT3; Urea transporter 1; Solute carrier family 14 member 1; Urea transporter B; UT-B; Urea transporter; erythrocyte
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
  • 基因功能參考文獻：
    1. Urea Transporter Protein is abnormally expressed in a rat model of hepatorenal syndrome induced by succinylated gelatin PMID: 26414230
    2. Report thiourea analogs as inhibitors of UT-B mediated urea transport. PMID: 25613743
    3. UT-B expression in the choroid plexus was reduced by high salt diet. PMID: 25869070
    4. Thienoquinoline PU-14 is a selective UT inhibitor and has urea-selective diuretic activity. PMID: 23486518
    5. Changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis. PMID: 18945830
    6. expression of urea transporters in short-loop DTL and DVR coincides with the development of the ability to produce a concentrated urine. PMID: 11832436

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Urea transporter family
  • 組織特異性：
    Expressed in brain, spleen, kidney, testis and lung, with highest levels in brain.
  • 數據庫鏈接：


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