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  4. Recombinant Rat THO complex subunit 1 (Thoc1)

Recombinant Rat THO complex subunit 1 (Thoc1)

  • 中文名稱：
    大鼠Thoc1重組蛋白
  • 貨號：
    CSB-YP023501RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Thoc1重組蛋白
  • 貨號：
    CSB-EP023501RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Thoc1重組蛋白
  • 貨號：
    CSB-EP023501RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Thoc1重組蛋白
  • 貨號：
    CSB-BP023501RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Thoc1重組蛋白
  • 貨號：
    CSB-MP023501RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Thoc1
  • Uniprot No.：
  • 別名：
    Thoc1; Da2-19; THO complex subunit 1; Tho1; Liver regeneration-related protein LRRG175; Nuclear matrix protein p84
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-343
  • 氨基酸序列
    MEYYSAIKNN DIMKFLSKWM GVEEIIPKAG KEPDVLQQTM DTENVVYLHN GLLLSYNDFM KFIGKWMELE YIILSEFCEE RASYTKLKRG VWKRSAPEDF LDKRPNKKIL IGNEELTRLW NLCPDNMEAC KLETREYMPI LEEFFEEAIE QADAENMVES EYKAINNSNY GWSTLRFLAW RSPHFFQPTN QQFKNMTEYL ENMVIKLAKE LPPHSEEIKT GEDEDEEDND ALLKENESPD VRQDKPITGE RIESLTNKLD EQWKILAPYL EIKDSDIRQI ECYSEDMKKR AKQLLVAWKD QEGVHETTDN LIGALNKSGL SDLAESLTND TETNSYLLSL LFY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. Essential for early embryonic development. Required for normal gene expression during postnatal testis development.
  • 亞細胞定位：
    Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm.
  • 數據庫鏈接：


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