在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Prosaposin (Psap), partial

Recombinant Rat Prosaposin (Psap), partial

  • 中文名稱：
    大鼠Psap重組蛋白
  • 貨號：
    CSB-YP018836RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Psap重組蛋白
  • 貨號：
    CSB-EP018836RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Psap重組蛋白
  • 貨號：
    CSB-EP018836RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Psap重組蛋白
  • 貨號：
    CSB-BP018836RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Psap重組蛋白
  • 貨號：
    CSB-MP018836RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Psap
  • Uniprot No.：
  • 別名：
    Psap; Sgp1; Prosaposin; Sulfated glycoprotein 1; SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D]
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 表達區域：
    310-389aa
  • 氨基酸序列
    NVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; Saposins are specific low-molecular mass non-enzymatic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
  • 基因功能參考文獻：
    1. Prosaposin is overexpressed following kainic acid-induced neurotoxicity PMID: 25461957
    2. Prosaposin secreted from mature neurons stimulates proliferation and maturation of immature neurons in the dentate gyrus. PMID: 24871372
    3. the alternatively spliced forms of mRNAs do not simply correspond to the precursor and intact forms of prosaposin. PMID: 24414178
    4. These findings suggest diverse functions for PSAP in the immune system. PMID: 23420452
    5. Abundant expression in the perinatal stages indicates the potential role of prosaposin in the early development of the rat brain. PMID: 21684311
    6. reconstruction of the order of internal duplications that gave rise to the four saposins by using phylogenetic tools PMID: 11734895
    7. The amount of prosaposin mRNA increased between days 14 and 45 after birth in normal retinas (rdy+), but not in the pathologic retinas (rdy-) of RCS rats. PMID: 15111580
    8. Stress, not via an increase of glucocorticoid hormone, transiently reduces hippocampal prosaposin levels. This phenomenon is followed by rapid recovery of the neurotrophin level, even when the stress stimulus persists PMID: 15132426
    9. Our results suggest that prosaposin plays a role in homeostasis in the peripheral auditory system PMID: 17156877
    10. Developmental expression of prosaposin is demonstrated within the normal rat cochlea/organ of Corti: inner hair cells and supporting cells, inner pillar cells, and synaptic region of the outer hair cells. PMID: 17167097
    11. Our results suggest that prosaposin is synthesized ubiquitously in neurons of both the central and peripheral nervous systems. PMID: 17763872
    12. Our findings indicate that the saposin B domain of prosaposin, which is the domain affected by alternative splicing, plays an important role in both neurons and microglia during neuroregeneration. PMID: 18022721
    13. Prosaposin aids survival of PC-12 cells from oxidative stress not only by reducing the phosphorylation levels of JNK and p38, but also by regulating the c-Jun/AP-1 pathway. PMID: 18706485
    14. Prosaposin was down-regulated in aging rat myocardium and kidney. PMID: 19471889

    顯示更多

    收起更多

  • 亞細胞定位：
    Lysosome.; [Prosaposin]: Secreted.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲综合一区无码精品| av免费网站在线观看| 在线成人精品国产区免费| 国产又黄又猛又粗又爽的a片动漫 成年女性特黄午夜视频免费看 | 国产精品无码久久四虎| 天堂网在线观看| 欧美性大战xxxxx久久久| 吃奶呻吟打开双腿做受在线视频| 日韩精品无码免费一区二区三区| 另类亚洲小说图片综合区| 99国产精品久久久久久久久久久| 精品国产av 无码一区二区三区| 性色欲情网站iwww| 无码不卡中文字幕av| 亚洲日韩国产精品无码av| 伊人亚洲大杳蕉色无码| 欧美巨大另类极品videosbest| 国产精品色情国产三级在| 男女午夜猛烈啪啦啦视频| 免费毛儿一区二区十八岁| 中文字幕一区二区人妻| 国内大量揄拍人妻在线视频| 欧美处交wwwvideos另类| 国产曰批免费视频播放免费| 国产美女自慰在线观看| 99蜜桃臀久久久欧美精品网站| 国产在线无码不卡影视影院| 黑人大战欲求不满人妻| 国产精品妇女一二三区| 337p日本欧洲亚洲大胆色噜噜| 国产精品色拉拉| 黑人巨大av无码专区| 成 年 人 黄 色 大 片大 全| 成年午夜性影院免费观看| 日韩免费无码视频一区二区三区| 2020久热爱精品视频在线观看 | 护士人妻hd中文字幕| 国产在线精品一区二区不卡麻豆| 国产偷伦视频片免费视频| 国产无遮挡a片又黄又爽漫画 | 国产成a人亚洲精品无码樱花|