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  4. Recombinant Rat Steroidogenic acute regulatory protein, mitochondrial (Star)

Recombinant Rat Steroidogenic acute regulatory protein, mitochondrial (Star)

  • 中文名稱：
    大鼠Star重組蛋白
  • 貨號：
    CSB-YP022798RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Star重組蛋白
  • 貨號：
    CSB-EP022798RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Star重組蛋白
  • 貨號：
    CSB-EP022798RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Star重組蛋白
  • 貨號：
    CSB-BP022798RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Star重組蛋白
  • 貨號：
    CSB-MP022798RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Star; Steroidogenic acute regulatory protein; mitochondrial; StAR; START domain-containing protein 1; StARD1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    63-284
  • 氨基酸序列
    EATLYSDQ ELSYIQQGEE AMQKALGILN NQEGWKKESQ QENGDEVLSK VVPGVGKVFR LEVLLDQPMD RLYEELVDRM EAMGEWNPNV KEIKVLKKIG KDTVITHELA AAAAGNLVGP RDFVSVRCTK RRGSTCVLAG MATHFGEMPE QSGVIRAEHG PTCMVLHPLA GSPSKTKLTW LLSIDLKGWL PKTIINQVLS QTQIEFASHL RKRLESSPAS EAQC
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
  • 基因功能參考文獻：
    1. GATA6 and StAR steroidogeneic genes are hypomethylated at specific CpG sites in prenatally androgenized rats PMID: 29859221
    2. Data suggest that aflatoxin B1 binds to hydrophobic binding pocket of inkdsB (3-deoxy-manno-octulosonate cytidylyltransferase from Acinetobacter baumannii) used in these in silico studies as a molecular model for StAR (steroidogenic acute regulatory) protein in rats. PMID: 24728861
    3. Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats. PMID: 27511375
    4. In vivod-Asp administration induced serum LH release, causing indirect increase of androstenedione and testosterone levels by enhancing StAR, cytochrome P450 cholesterol side-chain cleavage enzyme and 3beta-hydroxysteroid dehydrogenase isomerases mRNA levels PMID: 24713504
    5. Estradiol action at the membrane leads to the augmentation of neuroprogesterone synthesis through increasing cAMP, activation of protein kinase A, and the phosphorylation of translocator protein TSPO and StAR in hypothalamic astrocytes. PMID: 24877623
    6. By effect of neonatal benzo[a]pyrene exposure we found a decreased serum testosterone level and reduced StAR mRNA expression that persisted to adulthood. PMID: 22960446
    7. Postinfarction expression of nonsteroidogenic StAR in cardiac fibroblasts has novel antiapoptotic activity. PMID: 23831818
    8. Leptin, which inhibits the ovulatory process, caused a significant reduction in the ovarian expression of P450scc without changes in StAR or 3betaHSD. PMID: 23332974
    9. Tianoan zhuangyang powder could increase stAR protein expression in rats with partial androgen deficiency of aging male. PMID: 21608230
    10. Atrazine induced alterations in the mRNA transcript copy numbers of steroidogenesis genes: steroidogenic acute regulatory protein, CYP11A1 and 3beta-hydroxysteroid dehydrogenase were shifted toward the control values by kolaviron. PMID: 22674924
    11. There was no difference in StAR gene expression in the testis after DEHP treatment. PMID: 20568448
    12. StAR is a gene under the dual regulation of Bmal1 and Rev-erba. PMID: 22425774
    13. Downregulated StAR and 3-beta-HSD significantly contribute to low testosterone in hypoxic rats and are associated with ER stress, which mediates testis damage caused by oxygen deprivation. PMID: 22226148
    14. varicocele impaired Leydig cell function by increasing apoptosis and suppressing expression of the StAR protein PMID: 21076439
    15. Binding of steroidogenic factor-1 (SF-1) to the StAR promoter region was also enhanced by PTU treatment, which suggests that propylthiouracil could upregulate StAR gene expression. PMID: 20924043
    16. increased expressions of PKG I and StAR complex, accompanied by decreased PDE5 activity, suggest that NO-cGMP signalling pathway and consequent activation of StAR protein regulate the adaptive response of Leydig cells to repeated immobilization stress. PMID: 20039971
    17. morphological aspects of StarD6 were significantly different from those of StAR in cultured glial and neuronal cells, as well as the distribution in the normal and epileptic rat hippocampus PMID: 20609383
    18. FGF2 inhibited the expressions of steroidogenic acute regulatory (StAR) protein and steroidogenic factor 1 (Nr5a1) in LH-stimulated immature Leydig cells. PMID: 19814654
    19. repressed by transcription factor yin yang 1 PMID: 11861536
    20. Steroidogenic acute regulatory (StAR) protein in adrenal subcapsules (zona fasciculata/reticularis) was augmented by exposure to hypoxia; this effect was greatest at 5 days of age PMID: 12388447
    21. expression in cultured Schwann cells and its regulation by cAMP PMID: 12485839
    22. mRNA for an indispensable factor in aldosterone biosynthesis, the StAR protein, is expressed in rat heart and is up-regulated after myocardial infarction. PMID: 12697693
    23. modulation of DAX-1 and steroidogenic factor-1 intracellular levels in granulosa cells suggests that these transcription factors could be involved in mitogen-activated protein kinase suppression of steroidogenic acute regulatory protein expression PMID: 12727988
    24. interaction of hormone-sensitive lipase with StAR in cytosol increases the hydrolytic activity of HSL and that together HSL and StAR facilitate cholesterol movement from lipid droplets to mitochondria for steroidogenesis PMID: 12925534
    25. StAR is a naturally occurring mitochondrial protein that can serve as a substrate to probe multiple proteolytic activities in mammalian mitochondria. PMID: 12958217
    26. TNF alpha triggers different effector mechanisms to directly inhibit Leydig cell StAR expression and steroidogenesis, which ultimately contribute to the global reproductive failure associated with chronic inflammation and sepsis. PMID: 12959973
    27. StAR expression is developmentally regulated and that StAR may play some function in regulating cell proliferation in the brain. PMID: 14511326
    28. Lead alters basal StAR synthesis, but does not alter gonadotropin-stimulated StAR synthesis in ovaries of prepubertal rats. PMID: 14514953
    29. StAR protein is involved in neurosteroid production in ocular tissues. PMID: 14694755
    30. DAX-1 negatively regulates steroid synthesis through the inhibition of StAR expression and indicate that the absence of DAX-1 in R2C cells is, at least in part, responsible for the constitutive steroidogenesis and StAR expression observed. PMID: 15358680
    31. in both rats and mice in vivo, overexpression of StAR led to a marked increase in the rates of bile acid synthesis initiated by delivery of cholesterol to mitochondria containing CYP27A1. PMID: 15382124
    32. Arsenite and anisomycin may activate a novel MAP kinase which in part increases StAR expression through stabilizing the 3.5 kb mRNA but which may also activate a mechanism that by-passes transcription factors PMID: 15713539
    33. mRNA stability is coupled to transcription and translation, indicating that mRNA stability is coupled to these processes independent of the extended 3'-UTR. PMID: 16039847
    34. DG and DT have an inhibitory effect on corticosterone production via a Na+, K+-ATPase-independent mechanism by diminishing actions on cAMP-, Ca2+-pathway, competitive inhibition of P450scc enzyme and reduction of StAR mRNA expression. PMID: 16175571
    35. Reaction of neuronal nitrate synthase over the time of changes in Leydig cell steroidogenic acute regulatory protein and the peripheral-type benzodiazepine receptor. PMID: 16239298
    36. results revealed a decreased expression of mRNA of StAR during nephrosis PMID: 16574160
    37. Demonstrsates Star expression at the time of corpus luteum formation when c-ebpbeta peak. PMID: 16682116
    38. mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability. PMID: 17242178
    39. Dexamethasone increased DAX-1 expression and concordantly decreased StAR protein and mRNA in testicular cells. PMID: 17526944
    40. PGF2alpha enhances a direct YY1/StAR promoter interaction and the recruitment of HDAC1 to the promoter, thereby preventing transcriptional activation of the StAR gene. PMID: 17702849
    41. Prenatal exposure to nicotine elevated expression of StAR in maternal adrenals but descreased it in fetal adrenals. PMID: 17881205
    42. Results indicate that cyclic AMP signalling can regulate StAR expression and pregnenolone production in brain astrocytes. PMID: 17927664
    43. DHEA attenuated forskolin-stimulated SF-1 phosphorylation to affect StAR protein expression. PMID: 18004794
    44. Data suggest that down-regulation of StAR occurs during early stages of adrenal regeneration, and that the steroidogenic pathway is more sensitive to proteasome inhibitors than that regulating proliferative activity of regenerating adrenal cortex. PMID: 18425351
    45. protein kinase A-mediated phosphorylation of StAR protein is an important mechanism in the adaptive response of Leydig cells to repeated immobilization stress PMID: 18800309
    46. TNF-alpha, TNF-alpha receptors (TNFR1 and 2) and steroidogenic acute regulatory (StAR) protein expression during corpus luteum regression in albino Wistar rats PMID: 18990246
    47. Lycopene protects against PCB-induced changes in Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD. PMID: 19071209
    48. Letrozole-induced polycystic ovaries showed increased StAR expression. PMID: 19698287

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  • 亞細胞定位：
    Mitochondrion.
  • 數據庫鏈接：


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