在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Serine/threonine-protein kinase PAK 3 (Pak3)

  • 中文名稱:
    大鼠Pak3重組蛋白
  • 貨號:
    CSB-YP717286RA
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Pak3重組蛋白
  • 貨號:
    CSB-EP717286RA
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Pak3重組蛋白
  • 貨號:
    CSB-EP717286RA-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Pak3重組蛋白
  • 貨號:
    CSB-BP717286RA
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Pak3重組蛋白
  • 貨號:
    CSB-MP717286RA
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Pak3Serine/threonine-protein kinase PAK 3; EC 2.7.11.1; Beta-PAK; p21-activated kinase 3; PAK-3; p65-PAK
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-544
  • 氨基酸序列
    MSDSLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTGIPEQWAR LLQTSNITKL EQKKNPQAVL DVLKFYDSKE TVNNQKYMSF TSGDKSAHGY IAAHQSNTKT ASEPPLAPPV SEEEDEEEEE EEDDNEPPPV IAPRPEHTKS IYTRSVVESI ASPAAPNKEA TPPSAENANS STLYRNTDRQ RKKSKMTDEE ILEKLRSIVS VGDPKKKYTR FEKIGQGASG TVYTALDIAT GQEVAIKQMN LQQQPKKELI INEILVMREN KNPNIVNYLD SYLVGDELWV VMEYLAGGSL TDVVTETCMD EGQIAAVCRE CLQALDFLHS NQVIHRDIKS DNILLGMDGS VKLTDFGFCA QITPEQSKRS TMVGTPYWMA PEVVTRKAYG PKVDIWSLGI MAIEMVEGEP PYLNENPLRA LYLIATNGTP ELQNPERLSA VFRDFLNRCL EMDVDRRGSA KELLQHPFLK LAKPLSSLTP LILAAKEAIK NSSR
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC).
  • 基因功能參考文獻:
    1. specific loss of PAK3 expression and pharmacological inhibition of PAK both disrupt activity-dependent phosphorylation of S863 in cortical neurons PMID: 26460013
    2. Results show elevated PAK3 expression at both the mRNA and protein level in cJun/AP-1-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. PMID: 23818969
    3. PAK3 regulates activity-mediated rearrangement of synaptic connectivity associated with learning, suggesting that defects in spine formation and refinement during development could account for intellectual disability. PMID: 22238087
    4. A normal signaling pathway mediated by the interaction of amyloid precursor protein [APP], PAK3, and heterotrimeric Go protein is constitutively activated in neurons by familial Alzheimer mutations in APP causing cell cycle entry and consequent apoptosis PMID: 12890786
    5. Antisense and small interfering RNA-mediated suppression of PAK3 in rat hippocampal organotypic slice cultures results in the formation of abnormally elongated dendritic spines and filopodia-like protrusions and a decrease in mature spine synapses. PMID: 15574732
    6. the Cdc42/PAK3 is a key module in dendritic spine formation and synaptic plasticity PMID: 17537723
    7. While PAK1 and PAK3 share distinct roles in the regulation of spine morphogenesis, their activity may overlap, allowing compensation of the PAK3 deficit by PAK1. PMID: 18481281

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性:
    Detected at high levels in the brain and at low levels in the testis.
  • 數據庫鏈接:


主站蜘蛛池模板: 可以看三级的网站| 国偷自产视频一区二区久| 国产精品毛片无码| 朝鲜女人大白屁股ass| 亚洲一区波多野结衣在线| 国产成人午夜福利免费无码r| 国语自产偷拍精品视频偷| 老子午夜精品无码不卡 | 777米奇色狠狠俺去啦奇米77| 欧美mv日韩mv国产网站| 国产成人小视频| 欧美又粗又大又黄的片| 精品三级久久久久电影网| 蜜桃视频在线观看免费视频网站www | 国产成人av在线免播放观看| 成人性做爰aaa片免费| 亚洲午夜无码久久久久| 国产精品主播一区二区三区| 欧美精品久久96人妻无码| www国产无套内射com| 人妻丰满熟妇无码区免费| 精品国产免费观看久久久| 99re久久精品国产首页| 波多野结衣在线精品视频| 国产极品美女到高潮无套| 小12箩利洗澡无码视频网站| 男女啪动最猛动态图| 久久精品中文騷妇女内射| 成人亚洲欧美久久久久| 国产亚洲精品久久无码98| 久久无码人妻精品一区二区三区 | 国产在线不卡精品网站| 成人免费777777被爆出| 亚洲综合色婷婷七月丁香 | 欧美精品亚洲精品日韩传电影| 国产成人啪精品视频免费网站软件| 性按摩无码中文| 亚洲精品国产suv一区| 2021年国产精品专区丝袜| 中国xxx农村性视频| 国产真实夫妇视频|