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  4. Recombinant Rat Secreted frizzled-related protein 4 (Sfrp4)

Recombinant Rat Secreted frizzled-related protein 4 (Sfrp4)

  • 中文名稱：
    大鼠Sfrp4重組蛋白
  • 貨號：
    CSB-YP021140RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Sfrp4重組蛋白
  • 貨號：
    CSB-EP021140RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Sfrp4重組蛋白
  • 貨號：
    CSB-EP021140RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Sfrp4重組蛋白
  • 貨號：
    CSB-BP021140RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Sfrp4重組蛋白
  • 貨號：
    CSB-MP021140RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Sfrp4; Ddc4; Frp; Secreted frizzled-related protein 4; sFRP-4; DDC-4 protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    19-348
  • 氨基酸序列
    VR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST QENAILAIEQ YEELVDVNCS SVLRFFLCAM YAPICTLEFL HDPIKPCKSV CQRARDDCEP LMKMYNHSWP ESLACDELPV YDRGVCISPE AIVTDLPEDV KWIDITPDMM VQERSFDADC KHLSPDRCKC KKVKPTLATY LSKNYSYVIH AKIKAVQRSG CNEVTTVVDV KEIFKSSSPI PRTQVPLITN SSCQCPHILP HQDVLIMCYE RRSRMMLLEN CLVEKWRDQL SRRSTQWEER LQEQQRTTQD KKQIASRTSR SNPPKPKGRS PASKPASPKK NIKARSAPKK SNPKKSTS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
  • 基因功能參考文獻：
    1. Increased SFRP4 down-regulated the key gene beta-catenin, the downstream effectors gene ccnd1 and fibronectin expression in canonical Wnt pathway at the same time. PMID: 23200852
    2. Hydroxytyrosol alters several genes associated with cell proliferation, apoptosis and the Wnt signalling pathway, promoting a high expression of Sfrp4 in rat mammary tumors. PMID: 21120994
    3. Differential expression of secreted frizzled-related protein 4 in decidual cells during pregnancy. PMID: 12063187
    4. This study demonstrates an association between Secreted Frizzled Related Protein 4 and apoptosis during rat ovulation. PMID: 12815282
    5. Regulation of sFRP-4 by LH and PRL may be important for modulating Fz-1, known to be expressed in periovulatory follicles, and Wnt-4/Fz-4, which are expressed in corpora lutea. PMID: 12960062
    6. observations support the hypothesis that increased placental expression of SFRP4 inhibits the WNT pathway and thereby influences placental growth via effects on cell fate signaling PMID: 16540541

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Secreted frizzled-related protein (sFRP) family
  • 組織特異性：
    Expressed in the involuting mammary gland, ovarian corpus luteum and prostate. In ovaries, low levels found in granulosa cells. High levels in corpora lutea of pregnant animals.
  • 數據庫鏈接：


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