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  4. Recombinant Rat SH3 and multiple ankyrin repeat domains protein 1 (Shank1), partial

Recombinant Rat SH3 and multiple ankyrin repeat domains protein 1 (Shank1), partial

  • 中文名稱：
    大鼠Shank1重組蛋白
  • 貨號：
    CSB-YP893897RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Shank1重組蛋白
  • 貨號：
    CSB-EP893897RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Shank1重組蛋白
  • 貨號：
    CSB-EP893897RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Shank1重組蛋白
  • 貨號：
    CSB-BP893897RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Shank1重組蛋白
  • 貨號：
    CSB-MP893897RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Shank1; SH3 and multiple ankyrin repeat domains protein 1; Shank1; GKAP/SAPAP-interacting protein; SPANK-1; Somatostatin receptor-interacting protein; SSTR-interacting protein; SSTRIP; Synamon
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function.
  • 基因功能參考文獻：
    1. All three Shank mRNA isoforms are differentially expressed in the synaptic neuropil. PMID: 24298140
    2. this study provides a new level of understanding of the specificity and structural plasticity of the shank PDZ domain. PMID: 21376703
    3. Despite the fact that the betaPIX coiled-coil domain exposes three PDZ binding motifs in the C-termini, the betaPIX trimer associates with a single Shank PDZ. PMID: 20117114
    4. PDZ domain of Shank1 and its complex with the C-terminal octapeptide of GKAP were crystallized PMID: 12136153
    5. the rat shank1 PDZ-ligand complex has a class I PDZ interaction and a novel PDZ-PDZ dimerization PMID: 12954649
    6. The appearance of dendritic Shank mRNAs in cerebellar Purkinje cells coincides with the onset of dendrite formation. Expression of reporter transcripts in hippocampal neurons identifies a 200-nucleotide dendritic targeting element in Shank1 mRNA. PMID: 15121189
    7. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1. PMID: 19416473
    8. Promotes the maturation of dendritic spines and the enlargement of spine heads. Postsynaptic expression of Shank also enhances presynaptic function. PMID: 11498055

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Note=Colocalizes with alpha-latrotoxin receptor 1.
  • 蛋白家族：
    SHANK family
  • 組織特異性：
    Expressed only in brain (neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum).
  • 數(shù)據(jù)庫鏈接：


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