在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Rap guanine nucleotide exchange factor 2 (Rapgef2), partial

  • 中文名稱(chēng):
    大鼠Rapgef2重組蛋白
  • 貨號(hào):
    CSB-YP019330RA
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    大鼠Rapgef2重組蛋白
  • 貨號(hào):
    CSB-EP019330RA
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    大鼠Rapgef2重組蛋白
  • 貨號(hào):
    CSB-EP019330RA-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    大鼠Rapgef2重組蛋白
  • 貨號(hào):
    CSB-BP019330RA
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    大鼠Rapgef2重組蛋白
  • 貨號(hào):
    CSB-MP019330RA
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Rapgef2; Pdzgef1; Rap guanine nucleotide exchange factor 2; Cyclic nucleotide ras GEF; CNrasGEF; Neural RAP guanine nucleotide exchange protein; nRap GEP; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Ras/Rap1-associating GEF-1
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions.
  • 基因功能參考文獻(xiàn):
    1. Following cAMP elevation, neuritogenic cyclic AMP sensor/Rapgef2 is activated for signaling to ERK to mediate neuritogenesis, whereas Epac2 is activated for signaling to the MAP kinase p38 to mediate growth arrest. PMID: 24567337
    2. Data indicate that knockdown of Rapgef2 ablates cAMP-dependent ERK activation and neuritogenesis in neuronal cell line Neuroscreen-1 (NS-1). PMID: 23800469
  • 亞細(xì)胞定位:
    Cell membrane. Cytoplasm. Cytoplasm, perinuclear region. Late endosome. Cell junction.
  • 蛋白家族:
    RAPGEF2 family
  • 組織特異性:
    Expressed in the brain, heart, lung, liver and stomach. Expressed in the granular layer of the cerebellum. Expressed in Purkinje cells. Expressed in cortical neurons and coronary artery smooth muscle cells (at protein level). Expressed ubiquitously in the
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 成年午夜无码av片在线观看| 国产高清在线精品一区小说| 中国做爰国产精品视频| 九九九精品成人免费视频小说| 一区二区三区在线 | 欧洲| 无码av最新高清无码专区| 欧美成人一区二区三区片免费 | 国产黄a三级三级三级av在线看| 亚洲人成人无码网www国产| 色欲人妻aaaaaa无码| 国产av天堂亚洲国产av麻豆| 国产精品第12页| 99视频精品全部免费 在线| 国产精品特黄aaaa片在线观看| 男女啪啪网站大全免费| 国产午夜精品av一区二区 | 久久在线视频免费观看| 日韩理论午夜无码| 精品国产高清自在线一区二区 | 欧美牲交a欧美牲交aⅴ一| 一本久久综合亚洲鲁鲁五月天 | 一本大道东京热无码aⅴ| 亚洲国产精品成人精品无码区在线| 久久精品私人影院免费看| 一本一久本久a久久精品综合| 伊人色综合一区二区三区| 亚洲欧美国产另类va| 国产在线观看无码不卡| 久久久亚洲精品一区二区三区浴池| 特黄特色的大片观看免费视频| 色综合视频一区中文字幕| 国产免费高清69式视频在线观看| 新国产三级视频在线播放| 天堂俺去俺来也www色官网| 狠狠久久精品中文字幕无码 | 99亚洲乱人伦aⅴ精品| 少妇荡乳情欲办公室456视频| 一区三区不卡高清影视| 亚洲成l人在线观看线路| 老熟女五十路乱子交尾中出一区| 97影院理论午夜伦不卡|