Recombinant Rat Protein jagged-1 (Jag1), partial

中文名稱：

大鼠Jag1重組蛋白
貨號：

CSB-YP730923RA
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Jag1重組蛋白
貨號：

CSB-EP730923RA
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Jag1重組蛋白
貨號：

CSB-EP730923RA-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Jag1重組蛋白
貨號：

CSB-BP730923RA
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Jag1重組蛋白
貨號：

CSB-MP730923RA
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Jag1
Uniprot No.：

Q63722
別名：

Jag1Protein jagged-1; Jagged1; CD antigen CD339
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis.
基因功能參考文獻：
1. Overexpression of Jagged1 ameliorates aged rat-derived endothelial progenitor cell functions and increases its transfusion efficiency for balloon-induced rat arterial injury. PMID: 28163178
2. Jag1 can attenuate restenosis of vein graft by inducing decreased proliferation and increased apoptosis in vivo. PMID: 25660475
3. Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. PMID: 24907271
4. This is the first study to demonstrate that Jagged1 delivery transiently activates Notch signaling and increases osteogenesis. PMID: 23775982
5. an imbalanced interaction of Jagged1 expression in periductal and periportal myofibroblasts and Notch2 expressed in cholangiocytes, may be involved in the formation of bile duct lesions in Polycystic kidney rats PMID: 23331119
6. Data indicated that Recombinant Rat Jagged 1 Fc Chimera promoted adipogenic differentiation of mouse adipose-derived stem cells. PMID: 23046039
7. Jagged1 protein can activate Notch signal and enhance the differentiation of MSC into cardiomyocyte, while the effect can be inhibited by DAPT PMID: 16413496
8. Jagged1 may play a critical role in mediating the parathyroid hormone (PTH)-dependent expansion of hematopoietic stem cells, as well as the anabolic effect of PTH in bone PMID: 16647886
9. Recombinant rat Jagged-1-mediated signaling induces a unique form of human T cell suppression whereby T cells proliferate normally upon secondary stimulation but secrete significantly reduced levels of cytokine. PMID: 17475842
10. Jagged1 enhances the self-renewal of neural crest stem cells in vitro without affecting their sensitivity to instructive differentiation signals. PMID: 17761753
11. Ageing enhanced vascular smooth muscle proliferation through impaired endothelial cell Jagged1 expression after vascular injury. PMID: 18079106
12. mRNA expression of Notch-1 and its ligand Jagged-1 is upregulated in postnatal rat microglia of the corpus callosum and subventricular zone, but that of Delta-1 is reduced. PMID: 18449946
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
組織特異性：

Widely expressed in a variety of tissues.
數據庫鏈接：

KEGG: rno:29146

STRING: 10116.ENSRNOP00000010638

UniGene: Rn.88804