在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Protein cereblon (Crbn)

In Stock
  • 貨號:
    CSB-CF710067RA
  • 規格:
    ¥5268
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length
  • 來源:
    in vitro E.coli expression system
  • 分子量:
    52.4 kDa
  • 表達區域:
    1-445aa
  • 氨基酸序列
    MAGEGDHQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEARKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVMMILIPGQTLPLQLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPISWEDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKEDSLPANPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
  • 基因功能參考文獻:
    1. Aerobic exercise training decreases cereblon level in the skeletal muscle of diabetic rats. PMID: 29730289
    2. In neonatal cardiomyocytes, overexpression of CRBN significantly reduced AMPK activity, as demonstrated by reductions in both phosphorylation levels of AMPK and the expression of its downstream target genes. PMID: 24755080
    3. CRBN directly interacts with the alpha1 subunit of AMP-activated protein kinase (AMPK alpha1) and inhibits the activation of AMPK activation. PMID: 21232561
    4. CRBN may play an important role in assembly and surface expression of functional BK(Ca) channels by direct interaction with the cytosolic C-terminus of its alpha-subunit. PMID: 16045448
    5. Crbn is expressed in the retina and binds to voltage-gated chloride channels. PMID: 19166841

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    CRBN family
  • 組織特異性:
    Detected in heart, brain, liver, kidney and testis (at protein level). Ubiquitous.
  • 數據庫鏈接:


主站蜘蛛池模板: 真实国产精品vr专区| 无码人妻精品一区二区| 波多野结衣的av一区二区三区| 真人做人试看60分钟免费视频| 久久精品亚洲乱码伦伦中文| 成 人 网 站 免费观看| 一本一本久久aa综合精品| 国产午夜精品一区二区三区| 播放男人添女人下边视频| 亚洲人成色777777精品音频| 日日拍夜夜嗷嗷叫|日日摸| 天天天天噜在线视频| 2019日韩中文字幕mv| 日产精品一区二区| 日本新janpanese乱熟| 国产av区男人的天堂| 午夜福利日本一区二区无码| 精品午夜福利无人区乱码一区| 国产亚洲日韩欧美一区二区三区 | 亚洲日韩a∨无码久| 国产在线精品一品二区| 亚洲中文字幕一区精品自拍| 国产成人无码精品午夜福利a | 无码av中文一区二区三区| 久久麻豆成人精品av| 精品乱码一区内射人妻无码| 真人做作爱视频| 亚洲丁香五月激情综合| 亚洲国产无套无码av电影| 大伊香蕉精品一区视频在线| 男女裸交免费无遮挡全过程| 国产成人亚洲精品另类动态 | 香港三日本8a三级少妇三级99| 重口sm一区二区三区视频| 99久久99视频只有精品| 国产av丝袜旗袍无码网站 | 亚洲日韩乱码久久久久久| 国产日韩精品欧美2020区| 国产理论剧情大片在线播放| 夜夜高潮夜夜爽夜夜爱| 香蕉av福利精品导航|