在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Presenilin-2 (Psen2), partial

Recombinant Rat Presenilin-2 (Psen2), partial

  • 中文名稱：
    大鼠Psen2重組蛋白
  • 貨號：
    CSB-YP018847RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Psen2重組蛋白
  • 貨號：
    CSB-EP018847RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Psen2重組蛋白
  • 貨號：
    CSB-EP018847RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Psen2重組蛋白
  • 貨號：
    CSB-BP018847RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Psen2重組蛋白
  • 貨號：
    CSB-MP018847RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Psen2; Ps2; Psnl2; Presenilin-2; PS-2; EC 3.4.23.-) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
  • 基因功能參考文獻：
    1. Significant dysregulation of presenilin 2 gene was found in neuronal cells following brain ischemia due to cardiac arrest. PMID: 26721367
    2. a rare non-conservative single-nucleotide polymorphism was detected in the PSEN2 gene (P334R) in a large kindred with familial late-onset AD. PMID: 11803125
    3. The finding of presenilin-2 in the heart and the responsiveness to low glucose and hypoxia suggests that PS2 may be regulated by conditions of ischemia, a condition which both the heart and brain may experience. PMID: 12468103
    4. Calmyrin binds specifically endogenous preseninin-2 (PS2) and not PS1. PMID: 16257512
    5. PS2-LP-mediated alteration of intracellular Ca(2+) homeostasis may be linked to the acceleration of apoptosis PMID: 16603547
    6. These findings indicated that mutant presenilin 2 clearly increases oxidative stress and p53 expression, which could be implicated in promoting mutant presenilin 2-induced neurodegeneration in Alzheimer's disease. PMID: 17418105
    7. Ablation of presenilins results in deficiency of CD8 cells in the periphery and a dramatic change in the physiology of thymocytes. PMID: 17626841

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase A22A family
  • 數據庫鏈接：


主站蜘蛛池模板： 久久精品人人做人人爽| 爆乳护士一区二区三区在线播放| 成人欧美一区在线视频| 宅男66lu国产在线观看| 人妻出差精油按摩被中出| 亚洲一卡二卡三卡四卡无卡麻豆| 巨爆乳中文字幕爆乳区| 亚洲熟妇色xxxxx亚洲| 国色天香国产精品| 自拍偷在线精品自拍偷免费| 国产草草影院ccyycom| 国产成人精品无码专区| 亚洲欧美日本久久综合网站| 男女性爽大片视频免费看| 欧洲美女熟乱av| 四川丰满妇女毛片四川话| 国精品午夜福利视频不卡| 蜜臀av色欲a片无码一区| 4hu亚洲人成人无码网www电影首页 | 国产网友自拍在线视频| 久久久精品久久久久久96| 无码人妻少妇久久中文字幕蜜桃| 伊人久久大香线蕉综合75| 国内精品国产三级国产av| 国内精品久久久久久久久齐齐| 国产美女露脸口爆吞精| 免费无码一区二区三区蜜桃| 亚洲色成人www永久网站| 午夜av亚洲一码二中文字幕青青| 97夜夜澡人人爽人人模人人喊| 蜜桃久久精品成人无码av| 欧美孕妇乳喷奶水在线观看| 亚洲精品在看在线观看 | 人人妻一区二区三区| 卡1卡2卡3精品接入口| 动漫无遮挡h纯肉亚洲资源大片| 国精产品一二三区精华液| 亚洲精品人成网线在线播放va | 超薄肉色丝袜一区二区| 亚洲国产aⅴ成人精品无吗| 午夜伦4480yy私人影院|