在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Inppl1), partial

Recombinant Rat Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (Inppl1), partial

  • 中文名稱：
    大鼠Inppl1重組蛋白
  • 貨號：
    CSB-YP893910RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Inppl1重組蛋白
  • 貨號：
    CSB-EP893910RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Inppl1重組蛋白
  • 貨號：
    CSB-EP893910RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Inppl1重組蛋白
  • 貨號：
    CSB-BP893910RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Inppl1重組蛋白
  • 貨號：
    CSB-MP893910RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Inppl1; Ship2; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; EC 3.1.3.86; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification.
  • 基因功能參考文獻：
    1. candidate for type 2 diabetes PMID: 12086927
    2. modulation of the functional status of SHIP2 may be a major mechanism of insulin resistance induced by denervation. PMID: 12453826
    3. SHIP2 regulates PDGF- and IGF-I-mediated signaling downstream of PI3-kinase, leading to the antiapoptotic effect via 5-phosphatase activity, and regulates the growth factor-induced Ras-MAPK pathway mainly via the SH2 domain. PMID: 12933696
    4. Hepatic SHIP2 has an impact in vivo on the glucose metabolism in both physiological states possibly by regulating hepatic gene expression, when tranfected into mice. PMID: 15983195
    5. SHIP2-mediated negative feedback on PIP(3) coordinately works with the PI3-kinase-mediated positive feedback to maintain proper neurite outgrowth. PMID: 17535963

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, lamellipodium. Nucleus. Nucleus speckle. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring.
  • 蛋白家族：
    Inositol 1,4,5-trisphosphate 5-phosphatase family
  • 數據庫鏈接：


主站蜘蛛池模板： 日韩精品人涩人| 老太婆性杂交视频| 色资源av中文无码先锋| 国产亚洲色婷婷久久99精品| 久久综合色一综合色88| 任我爽橹在线精品视频| 国产乱人伦精品一区二区在线观看| 国产麻豆md传媒视频| 高潮毛片无遮挡高清视频播放| 国产午夜片无码区在线观看爱情网| 成人网站www污污污网站 | 97色伦97色伦国产欧美| 越南女子杂交内射bbwxz| 国产婷婷色一区二区三区 | 国产精品久久久久久无码五月| 午夜嘿嘿嘿在线观看| 国产熟女内射oooo| 成熟女人毛片www免费版在线| 人禽无码视频在线观看| 国产精品激情欧美可乐视频| 亚洲熟妇无码八v在线播放| 国产欧美精品一区二区三区 | 亚洲欧美日韩国产成人| 99久久免费国产精品| 亚洲欧美日韩国产精品一区| 67194熟妇在线观看线路| 亚洲欧美日韩成人一区| 人妻人人澡人人添人人爽人人玩 | 最近免费中文字幕mv在线视频3| 久久国产精品免费一区二区三区| 精品久久久久中文字幕加勒比| 日本一区二区三区不卡免费| 日本xxxxx片免费观看喷水 | 中文字幕乱妇无码av在线| 日韩欧无码一区二区三区免费不卡| 精品亚洲国产成人av不卡| 人人妻人人澡av| 国产爆乳无码一区二区麻豆| 国产色青青视频在线观看撒| 国产日产高清欧美一区| 国产强被迫伦姧在线观看无码|