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  4. Recombinant Rat Peptidyl-prolyl cis-trans isomerase FKBP1B (Fkbp1b)

Recombinant Rat Peptidyl-prolyl cis-trans isomerase FKBP1B (Fkbp1b)

  • 中文名稱：
    大鼠Fkbp1b重組蛋白
  • 貨號：
    CSB-YP008692RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Fkbp1b重組蛋白
  • 貨號：
    CSB-EP008692RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Fkbp1b重組蛋白
  • 貨號：
    CSB-EP008692RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Fkbp1b重組蛋白
  • 貨號：
    CSB-BP008692RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Fkbp1b重組蛋白
  • 貨號：
    CSB-MP008692RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Fkbp1b
  • Uniprot No.：
  • 別名：
    Fkbp1bPeptidyl-prolyl cis-trans isomerase FKBP1B; PPIase FKBP1B; EC 5.2.1.8; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; Calstabin-2; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-108
  • 氨基酸序列
    GVEIETISP GDGRTFPKKG QICVVHYTGM LQNGKKFDSS RDRNKPFKFR IGKQEVIKGF EEGAAQMSLG QRAKLTCTPD VAYGATGHPG VIPPNATLIF DVELLNLE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
  • 基因功能參考文獻：
    1. raising FKBP1b reversed calcium dysregulation and memory impairment in aging rats, allowing them to perform a memory task as well as young rats PMID: 26224869
    2. Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor 2 in bronchial smooth muscle cells is responsible for the increased calcium response contributing to AHR in asthma PMID: 24053175
    3. Disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging. PMID: 21289178
    4. Characterize the kinetics of FKBP12/12.6 binding to RyR2 in ventricular myocytes and effects on calcium signaling. PMID: 20431056
  • 亞細胞定位：
    Cytoplasm. Sarcoplasmic reticulum.
  • 蛋白家族：
    FKBP-type PPIase family, FKBP1 subfamily
  • 組織特異性：
    Detected in heart muscle (at protein level). Ubiquitous.
  • 數據庫鏈接：


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