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  4. Recombinant Rat Paired box protein Pax-4 (Pax4)

Recombinant Rat Paired box protein Pax-4 (Pax4)

  • 中文名稱：
    大鼠Pax4重組蛋白
  • 貨號：
    CSB-YP017490RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pax4重組蛋白
  • 貨號：
    CSB-EP017490RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pax4重組蛋白
  • 貨號：
    CSB-EP017490RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pax4重組蛋白
  • 貨號：
    CSB-BP017490RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pax4重組蛋白
  • 貨號：
    CSB-MP017490RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pax4
  • Uniprot No.：
  • 別名：
    Pax4Paired box protein Pax-4
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-349
  • 氨基酸序列
    MQQDGLSSVN QLGGLFVNGR PLPLDTRQQI VQLAIRGMRP CDISRSLKVS NGCVSKILGR YYRTGVLEPK GIGGSKPRLA TPAVVARIAQ LKDEYPALFA WEIQRQLCAE GLCTQDKAPS VSSINRVLRA LQEDQRLHWT QLRSPAVLAP ALPSPHSNCE APRGPHPGTS HRNRTIFSPG QAEALEKEFQ RGQYPDSVVR GKLAAATSLP EDTVRVWFSN RRAKWRRQEK LKWETQMPGA SQDLMVPKDS PGIISAQQSP GSVPSAALPV LEQLNPSFCQ LCWGAVPDRC SSDTTSQACL QPYWECHSLL PVASSSYMEF AWPCLTTHPV HHLIGGPGQA PSTYYLHWP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters.
  • 基因功能參考文獻：
    1. The Pax4 transcripts were detected in adult rat islets, and levels were induced by the mitogens activin A and betacellulin. PMID: 15596543
    2. activation of Pax4 in Pdx1-VP16-expressing cells reprograms pancreatic precursor-like WB-1 cells into glucose-responsive, more mature insulin-producing cells PMID: 16732298
    3. Causal association between Pax4 mRNA levels and susceptibility of rat insulinoma cells to apoptosis suggests an important physiological function for Pax4 in cell survival. PMID: 17260022
    4. The daily changes in Pax4 expression may influence gene expression in the pineal gland. PMID: 18818287
    5. The daily rhythm in pineal Pax4 expression is controlled by a neural system which acts on pinealocytes through an adrenergic-cyclic AMP signalling mechanism. PMID: 18818287
    6. Pineal expression of Pax4 is undetectable prior to birth and increases thereafter; in the adult there is a daily rhythm in Pax4 expression with high levels during the day. PMID: 18818287
    7. Retinal expression of Pax4 is undetectable prior to birth but increases thereafter; in the adult there are daily changes which may influence retinal gene expression PMID: 19012751

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 組織特異性：
    Specifically expressed in pancreatic islets.
  • 數據庫鏈接：


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