在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat POU domain, class 4, transcription factor 1 (Pou4f1)

Recombinant Rat POU domain, class 4, transcription factor 1 (Pou4f1)

  • 中文名稱：
    大鼠Pou4f1重組蛋白
  • 貨號：
    CSB-YP018400RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pou4f1重組蛋白
  • 貨號：
    CSB-EP018400RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pou4f1重組蛋白
  • 貨號：
    CSB-EP018400RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pou4f1重組蛋白
  • 貨號：
    CSB-BP018400RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pou4f1重組蛋白
  • 貨號：
    CSB-MP018400RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pou4f1
  • Uniprot No.：
  • 別名：
    Pou4f1; Brn-3; Brn3; Brn3a; POU domain; class 4; transcription factor 1; Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-128
  • 氨基酸序列
    RRIKLGVTQA DVGSALANLK IPGVGSLSQS TICRFESLTL SHNNMIALKP ILQAWLEEAE GAQREKMNKP ELFNGGEKKR KRTSIAAPEK RSLEAYFAVQ PRPSSEKIAA IAEKLDLKKN VVRVWFCN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site.; Able to act as transcription factor, cannot regulate the expression of the same subset of genes than isoform 1. Does not have anitapoptotic effect on neuronal cells.
  • 基因功能參考文獻：
    1. phenotypic and molecular changes that may represent an effort to resist degeneration and/or preferential survival of m+RGCs capable of synthesizing Brn3a. PMID: 26200499
    2. Brn3a is a reliable retinal ganglion cell marker that can be used to accurately measure the potential effect of a given neuroprotective therapy. PMID: 21315070
    3. Prenatal lead exposure caused a significant decrease in Brn-3a mRNA transcription in neural cells from cerebral hippocampus. PMID: 18839516
    4. Brn-3a mRNA transcription level significantly decreased in neural cells from cerebral hippocampus in all lead treatment groups compared with the control group. PMID: 18303621
    5. data define AR as a direct Brn-3a interactor and verify a simple interacting protein prediction methodology that is likely to be useful for many other proteins PMID: 20228055
    6. Brn-3a activates transcription of anti-apoptotic genes in retinal ganglion cells. PMID: 15968082

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    POU transcription factor family, Class-4 subfamily
  • 組織特異性：
    Detected in brain, spinal cord and dorsal root ganglion. Isoform 2 is detected in brain, spinal cord, dorsal root ganglion and spleen.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 高潮毛片无遮挡高清免费视频| 国产精品自在在线午夜| 国产精品刮毛| 色欲色香天天天综合网站 | 国产成人综合日韩精品无码不卡| 伴郎粗大的内捧猛烈进出视频观看 | 无码人妻精品一区二| 国产亚洲精品福利视频在线观看| 久久精品人人做人人综合| 人人妻人人澡人人爽欧美精品| 亚洲a∨无码一区二区三区| 成人免费xxxxx在线观看| 三上悠亚的av片在线无码| 久久久久久亚洲精品a片成人| 欧美真人性做爰全过程| 波多野结衣一区二区三区高清| 中文字幕v亚洲日本在线| 国产精品无码久久四虎| 国产精品99久久久久久人| 东北少妇不戴套对白第一次| 人人人插人人费| 亚洲精品一区久久久久| 综合无码一区二区三区| 亚洲欧美日韩中文播放| 中本亚洲欧美国产日韩| 搡老女人老妇女老熟妇| 国产一区二区三区| 精品日产卡一卡二卡麻豆| 欧美高清大屁股xxxxx| 久久香蕉国产线看观看精品yw| 男人添女人下部高潮视频| 真实国产精品视频400部| 日本不卡一区二区三区| 欧美乱妇狂野欧美在线视频| 人妻av中文字幕一区二区三区| 亚洲成 人 综合 亚洲欧洲| 18禁成人网站免费观看| 永久免费看啪啪的网站| 国产传媒精品1区2区3区| 亚洲成av人片香蕉片| 在线涩涩免费观看国产精品|