在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Orexin receptor type 2 (Hcrtr2), partial

Recombinant Rat Orexin receptor type 2 (Hcrtr2), partial

  • 中文名稱：
    大鼠Hcrtr2重組蛋白
  • 貨號：
    CSB-YP010232RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Hcrtr2重組蛋白
  • 貨號：
    CSB-EP010232RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Hcrtr2重組蛋白
  • 貨號：
    CSB-EP010232RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Hcrtr2重組蛋白
  • 貨號：
    CSB-BP010232RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Hcrtr2重組蛋白
  • 貨號：
    CSB-MP010232RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hcrtr2; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2R; Hypocretin receptor type 2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
  • 基因功能參考文獻：
    1. Study using specific orexin receptor antagonists suggests that the orexin 2 receptor has a dominant role in the observed effects of orexin A/hypocretin-1 . To our knowledge, this article is the first to show orexinergic modulation of the ventrolateral geniculate nucleus . PMID: 26724374
    2. the OX2 receptor has a critical role in modulating reward circuit in the Ventral Tegmental Area and Nucleus Accumbens PMID: 26494513
    3. Activation of orexin perifornical hypothalamus-rostral ventrolateral medulla (RVLM) neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia. PMID: 26653571
    4. Orexin 2 receptor (and orexin 1 receptor) contribute to the cardiovascular and locomotor response to stress. PMID: 25239810
    5. Orexins modifiy orexin receptor gene expression and gonadotropin release from the anterior pituitary gland. PMID: 24333629
    6. Elevated OX2R-mediated activity in the brain. PMID: 23525245
    7. Suggest a more prominent role for OX(2)R in ethanol self-administration compared to cue-conditioned ethanol-seeking. PMID: 23601187
    8. siRNA knockdown of OX2R in pontomesencephalic tegmentum increases duration of REM episodes. PMID: 23282008
    9. OX2R protein and mRNA are expressed in C6 glioma cells. PMID: 22588980
    10. In cultured rat cortical neurons, acting at OX2 receptors coupled to Gi protein, orexin inhibits cyclic AMP synthesis. PMID: 21547533
    11. These results demonstrate that orexins excite the cerebellar IN neurons through OX(2)R and suggest that the central orexinergic nervous system may actively participate in motor control through its modulation of the final outputs of the spinocerebellum PMID: 19921532
    12. Examine the role of hcrtR2 in nicotine's reinforcing effects. PMID: 20177882
    13. In developing hypoglossal motoneurons dissociated from 4-to 33-day-old rats, the number of mRNA copies of the orexin type 2 receptor identified per cell is significantly higher around day 20 postnatally than at any other age. PMID: 11930155
    14. Orexin Stimulation of amylase release by a pancreatic cell line is mediated by Orexin 2 receptors. PMID: 12409837
    15. Two distinct clusters of neurons containing orexin-B immunoreactivity within the amygdaloid complex may serve as a component of neuronal circuits involved in integrating complex homeostatic mechanisms associated with behaviors in the rat. PMID: 12650973
    16. Deterioration of the orexin system may play a role in the phenomenon associated with aging. PMID: 14749141
    17. Hypocretin, via the Hcrtr2 receptor, affects a specific subset of somatosensory cortex layer 6b neurons which, through corticocortical projections, may also be involved in promoting widespread cortical activation. PMID: 15282280
    18. hypocretins have roles in driving drug seeking through activation of stress pathways in the brain PMID: 16357203
    19. Thwe Ox2R signaling pathway was studied in rat olfactory mucosa and olfactory afferent neurons. PMID: 17292491
    20. Data suggest that muscarininc-2 and orexin-2 receptors may determine behavioral and state-regulating roles of GABA- and non-GABAergic neurons of the mesopontine reticular formation and lateral tegmentum and their dysfunction in narcolepsy with cataplexy. PMID: 18709662
    21. These results support a dual role for oxB/hcrt-2 in mediating glutamatergic transmission in the VTA, and suggest that oxA/hcrt-1 and oxB/hcrt-2 exert different roles in enhancing the motivational components of arousal and feeding. PMID: 18793323
    22. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. PMID: 19751316
    23. Orexin receptor expression was studies in various tissues. OX2R is sexually dimorphic expressed in adrenal glands. PMID: 11459774

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed in the brain in the cerebral cortex, septal nuclei, hippocampus, medial thalamic groups, dorsal and median raphe nuclei, and many hypothalamic nuclei including the tuberomammillary nucleus, dorsomedial hypothalamus, paraventricular hypothalamic
  • 數據庫鏈接：


主站蜘蛛池模板： 国产精品爽爽久久久久久| 日本xxxx片免费观看| 一区二区国产高清视频在线| 日韩欧美一区二区三区免费观看| 人妻少妇邻居少妇好多水在线 | 亚洲国产成人精品无码一区二区| 亚洲精品区午夜亚洲精品区| 欧美老熟妇乱子伦视频| 亚洲欧洲无码一区二区三区| 中文字幕人妻被公上司喝醉| 高清免费精品国自产拍| 中文字幕丰满孑伦无码专区| 久久亚洲精品成人av无码网站| 亚洲综合区小说区激情区| 8x国产精品视频| 777久久精品一区二区三区无码| 日日摸天天碰中文字幕你懂的| 中文字幕av无码人妻| 婷婷射精av这里只有精品| 脱岳裙子从后面挺进去在线观看 | 国产一区二区无码蜜芽精品 | 高清一区二区三区免费视频| 亚洲色偷拍另类无码专区| 国产国语毛片在线看国产| 国产精品美女久久久久久福利| 欧美成人国产精品高潮| 久久久国产精品消防器材| 日韩在线视频线观看一区| 日本www网站色情乱码| 污污污污污污www网站免费| 亚洲中文字幕婷婷在线| 欧美黑人巨大videos极品| 色偷偷偷在线视频播放| 人妻夜夜爽天天爽三区麻豆av网站 | 国产成人精品日本亚洲一区| 亚洲va中文字幕无码一二三区| 久久不见久久见免费影院 | 国产在线无码不卡影视影院| 奇米影视7777久久精品人人爽| 污污内射在线观看一区二区少妇| 亚洲日韩看片无码电影|