Recombinant Rat Nuclear pore glycoprotein p62 (Nup62)

中文名稱：

大鼠Nup62重組蛋白
貨號(hào)：

CSB-EP016204RA
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

大鼠Nup62重組蛋白
貨號(hào)：

CSB-EP016204RA-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Nup62重組蛋白
貨號(hào)：

CSB-MP016204RA
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Name:Nup62
Uniprot No.：

P17955
別名：

Nup62; Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-525
氨基酸序列

SGFNFGGTG APAGGFTFGT AKTATTTPAT GFSFSASGTG TGGFNFGTPS QPAATTPSTS LFSLATQTST TQTPGFNFGT TPASGGTGFS LGISTPKLSL SSTAATPATA NTGSFGLGSS TLTNAISGAS TSSQGTAPTG FVFGSSTTSA PSTGTTGFSF TSGSASQPGA SGFNIGSVGS LAQPTALSGS PFTPATLATT TAGATQPAAA TPTAATTSAG STLFASIAAA PASSSTTVLS LSAPATTAAT PTAGTLGFSL KAPGAAPGAS TTSTTTTTTT TTTTASTSSS TTTTGFALSL KPLVPAGPSS VAATALPASS TAVGTTTGPA MTYAQLESLI NKWSLELEDQ ERHFLQQATQ VNAWDRTLIE NGEKITSLHR EVEKVKLDQK RLDQELDFIL SQQKELEDLL SPLEESVKEQ SGTIYLQHAD EEREKTYKLA ENIDAQLKRM AQDLKDIIEH LNMAGGPADT SDPLQQICKI LNAHMDSLQW VDQSSALLQR RVEEASRVCE SRRKEQERSL RIAFD
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
基因功能參考文獻(xiàn)：
1. Data suggest that neuroprotection via ghrelin involves up-regulation of Bcl-2 (B cell lymphoma 2 associated oncogene) and p-62/Sqstm1 (ubiquitin-binding protein p62) plus down-regulation of LC3-II (microtubule-associated protein 1 light chain 3) and Beclin-1. Studies were conducted in adult hippocampal neural stem cells in primary culture. PMID: 29057768
2. complexes of Nup62 suggest the crucial role of the coiled-coil motifs in providing plasticity to various modular assemblies PMID: 28406021
亞細(xì)胞定位：

Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
蛋白家族：

Nucleoporin NSP1/NUP62 family
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:65274

STRING: 10116.ENSRNOP00000067556

UniGene: Rn.54450