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  4. Recombinant Rat Neuronal acetylcholine receptor subunit beta-4 (Chrnb4), partial

Recombinant Rat Neuronal acetylcholine receptor subunit beta-4 (Chrnb4), partial

  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-4(Chrnb4),partial
  • 貨號：
    CSB-YP005398RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-4(Chrnb4),partial
  • 貨號：
    CSB-EP005398RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-4(Chrnb4),partial
  • 貨號：
    CSB-EP005398RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-4(Chrnb4),partial
  • 貨號：
    CSB-BP005398RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit beta-4(Chrnb4),partial
  • 貨號：
    CSB-MP005398RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Chrnb4
  • Uniprot No.：
  • 別名：
    Chrnb4; Acrb4; Neuronal acetylcholine receptor subunit beta-4; Neuronal acetylcholine receptor non-alpha-2 chain; N-alpha 2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻：
    1. Four genes were significantly downregulated in the PFC [prefrontal cortex ]of SHR[spontaneously hypertensive rat ] compared to Wistar rats (Gad2, Chrnb4, Slc5a7, and Qrfpr) and none in nucleus accumbens. PMID: 25041985
    2. alpha6beta4* nAChRs are among the subtypes expressed by dorsal root ganglion neurons, and to our knowledge, this is the first demonstration of alpha6beta4* in neurons outside the CNS PMID: 22024738
    3. Loop 9 has a different role in the function of homomeric and heteromeric receptors. PMID: 20043866
    4. Immunocytochemistry revealed most chromaffin cells positive for beta4 proteins. And suggest that the most frequently encountered receptors of rat chromaffin cells should comprise alpha3beta4, alpha3beta2 with the addition of alpha5 subunits. PMID: 12814364
    5. Only residues belonging to two beta2 segments, 74-89 and 106-115, confer up-regulation to beta4, mainly by decreasing the amount of binding sites in the absence of nicotine; the beta4 microdomain is sufficient to confer to beta2 a beta4-like up-regulation PMID: 14764595

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Beta-4/CHRNB4 sub-subfamily
  • 組織特異性：
    In the brain, it is detected in the medial habenula. In the peripheral nervous system, it is found at least in the adrenal gland.
  • 數據庫鏈接：


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