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  4. Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10 (Chrna10), partial

Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10 (Chrna10), partial

  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10(Chrna10),partial
  • 貨號：
    CSB-YP872879RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10(Chrna10),partial
  • 貨號：
    CSB-EP872879RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10(Chrna10),partial
  • 貨號：
    CSB-EP872879RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10(Chrna10),partial
  • 貨號：
    CSB-BP872879RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Neuronal acetylcholine receptor subunit alpha-10(Chrna10),partial
  • 貨號：
    CSB-MP872879RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Chrna10
  • Uniprot No.：
  • 別名：
    Chrna10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10; NACHR alpha-10
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
  • 基因功能參考文獻：
    1. the contribution of subunit interface domains to alpha9alpha10 receptors by a combination of electrophysiological and radioligand binding studies, is reported. PMID: 28069778
    2. A two order of magnitude species difference in potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10 nAChR. PMID: 22774872
    3. mRNA expression of the nicotinic acetylcholine receptor alpha9 subunit precedes expression of the alpha10 subunit in both cochlear and vestibular hair cells. PMID: 21843604
    4. The properties of rat and chicken recombinant and native alpha9alpha10 receptors, were compared. PMID: 22371598
    5. permeability of the recombinant alpha 9 alpha 10 nicotinic acetylcholine receptor to Ca(2+), Ba(2+) and Mg(2+) and its modulation by these divalent cations PMID: 12117536
    6. Dorsal root ganglion neurons coexpress alpha 10 nicotinic acetylcholine receptor subunit with the alpha 9 subunit, thereby providing the first example of neuronal expression of this receptor subunit pair. PMID: 12401316
    7. developmental mRNA expression of the alpha10 nicotinic acetylcholine receptor subunit in the rat cochlea PMID: 12414097
    8. Nicotinic acetylcholine receptor alpha 10 subunit is localized in virtually all nociceptive neurons that are identified by immunoreactivity for the vanilloid receptor TRPV-1. PMID: 15296793
    9. Natural developmental down-regulation of alpha10, but not alpha9, supports the hypothesis that functional nicotinic acetylcholine receptors in inner hair cells are heteromers containing both these subunits. PMID: 15356192
    10. Results suggest a molecular mechanism for the treatment of neuropathic pain and also demonstrate the involvement of alpha9alpha10 nicotinic acetylcholine receptors in the pathophysiology of peripheral nerve injury. PMID: 17101979
    11. Distribution of this subunit in rat sympathetic ganglia; posslbe interaction wiwth polypeptide 7 subunit. PMID: 17192608
    12. Allografts were characterized by accumulations of alveolar macrophages strongly expressing the alpha9 and the alpha10 receptor subunit. PMID: 17331545
    13. Co-expression of the alpha10 subunit converts the normally weak acetylcholine-mediated activity of alpha9 to a more robustly active channel with identical physiological characteristics of the native mammalian outer hair cell cholinergic receptor. PMID: 11248107
    14. original cloning and developmental analysis of alpha10 expression PMID: 11248107

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  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-10/CHRNA10 sub-subfamily
  • 組織特異性：
    Expressed in the outer hair cells of the cochlea and the neurons of dorsal root ganglia.
  • 數據庫鏈接：


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