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  4. Recombinant Rat Neurexin-1 (Nrxn1), partial

Recombinant Rat Neurexin-1 (Nrxn1), partial

  • 中文名稱：
    大鼠Nrxn1重組蛋白
  • 貨號：
    CSB-YP714127RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Nrxn1重組蛋白
  • 貨號：
    CSB-EP714127RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Nrxn1重組蛋白
  • 貨號：
    CSB-EP714127RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Nrxn1重組蛋白
  • 貨號：
    CSB-BP714127RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Nrxn1重組蛋白
  • 貨號：
    CSB-MP714127RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Nrxn1; Neurexin-1; Neurexin I-alpha; Neurexin-1-alpha
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
  • 基因功能參考文獻：
    1. Results determined the crystal structures of the trimeric C1q-like domain of cerebellin-1, and the first complete ectodomain of GluD2. Cerebellin binds to the LNS6 domain of alpha- and beta-neurexin-1 through a high-affinity interaction that involves its highly flexible N-terminal domain. PMID: 27926833
    2. study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex. PMID: 27033232
    3. Structural and functional analyses of the sixth site of neurexin alternative splicing PMID: 26335821
    4. structure of Calsyntenin 3 and its interaction with neurexin 1alpha PMID: 25352602
    5. The results showed that AChE clusters colocalized with neurexin assemblies in the neurites of hippocampal neurons. PMID: 24594013
    6. Neurexin 1 can induce functional inhibitory synapse connections when presynaptic interneurons express a neurexin isoform that binds to neuroligin 1. PMID: 23426688
    7. Higher-order architecture of cell adhesion mediated by polymorphic synaptic adhesion molecules neurexin and neuroligin. PMID: 22840401
    8. Neurexin 1 binding to latrophilin-1 produces a stable intercellular adhesion complex. PMID: 22262843
    9. Neurexin-1alpha is a component of the beta-cell secretory machinery and contributes to secretory granule docking, most likely through interactions with granuphilin. PMID: 22235116
    10. Neurexin-1 is involved in the formation of the slit diaphragm of the glomerular podocytes in the kidney, and the maintenance of its function. PMID: 21048075
    11. Neurexin1 was upregulated in both frontal cortex and caudate putamen in hypoxia rats. PMID: 20945070
    12. the neurexin 1beta/neuroligin 1 complex has a role in synapse formation PMID: 15797875
    13. Neurexin-1 beta is perhaps most important for GABA synapse formation or controlling the balance of GABA and glutamate synapses PMID: 16624946
    14. The recognition properties of individual neuroligins toward beta-neurexin-1 (NX1beta), along with the influence of their splice inserts, were explored by surface plasmon resonance and affinity chromatography. PMID: 17042500
    15. Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses. PMID: 17868325
    16. beta-NRX insertion sequence 4 may function in roles independent of neuroligin binding. PMID: 18334216
    17. X ray structures reveal the mechanism by which neurexin 1beta isoforms acquire neuroligin splice isoform selectivity. PMID: 18334217
    18. Data show beta-cell expression of the neurexin 1, and demonstrate that the neurexins are expressed outside the central nervous system and help confer an inhibitory synaptic-like phenotype onto the beta-cell surface. PMID: 18755801

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane.
  • 蛋白家族：
    Neurexin family
  • 組織特異性：
    Brain (neuronal synapse).
  • 數據庫鏈接：

    KEGG: rno:60391

    UniGene: Rn.54924



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