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  4. Recombinant Rat Netrin receptor DCC (Dcc), partial

Recombinant Rat Netrin receptor DCC (Dcc), partial

  • 中文名稱：
    Recombinant Rat Netrin receptor DCC(Dcc) ,partial
  • 貨號：
    CSB-YP723559RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Netrin receptor DCC(Dcc) ,partial
  • 貨號：
    CSB-EP723559RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Netrin receptor DCC(Dcc) ,partial
  • 貨號：
    CSB-EP723559RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Netrin receptor DCC(Dcc) ,partial
  • 貨號：
    CSB-BP723559RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Netrin receptor DCC(Dcc) ,partial
  • 貨號：
    CSB-MP723559RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Dcc
  • Uniprot No.：
  • 別名：
    DccNetrin receptor DCC; Tumor suppressor protein DCC
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
  • 基因功能參考文獻：
    1. DCC activation of Src is required for NMDAR-dependent long-term potentiation and certain forms of learning and memory. PMID: 23291093
    2. Trio(Y2622) phosphorylation is essential for the regulation of the DCC/Trio signaling complex in cortical neurons during netrin-1-mediated axon outgrowth. PMID: 23230270
    3. Treadmill exercise has beneficial effects via involvement of netrin-1 and its receptors DCC and Unc5B in neuronal and vascular activities in brain-ischemic rats. PMID: 21820492
    4. DCC have Prominent Expression in Adult Schwann cells. PMID: 21656855
    5. Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems. PMID: 20628609
    6. DCC seen in lateral/apical sides of newly differentiating/secretory ameloblasts. DCC localized only in apical side of mature-stage ameloblasts not in lateral side. DCC expressed in differentiating ameloblasts, suggesting a crucial role in amelogenesis. PMID: 19362703
    7. Netrin-1 attracts mossy fibres via DCC under control conditions and repels them via UNC5A under hyperexcitable conditions. PMID: 19858080
    8. DCC performs dual roles both as a cell surface receptor that modulates intracellular signaling pathways and as a transcriptional coactivator that relies on gamma-secretase-dependent production and nuclear translocation of the cytoplasmic domain. PMID: 12840034
    9. Netrin-1 increases cell surface DCC; protein kinase A potentiates the mobilization of DCC to the neuronal plasma membrane from an intracellular vesicular store, and translocation of DCC to the cell surface increases axon outgrowth in response to netrin-1 PMID: 15044543
    10. Significant DCC-immunoreactivity was detected in midbrain, where it was localized to ventrally displaced A9 dopamine neurons in the substantia nigra, and ventromedial A10 dopamine neurons predominantly situated in and around the interfascicular nucleus. PMID: 15730872
    11. DCC was expressed both in neurons and astrocytic feet with a peak at 14 days after ischemia. PMID: 17574219
    12. DCC interacts with Fyn, both in the lipid rafts and soluble compartments isolated from embryonic E19 rat brains. PMID: 18616430
    13. Netrin 1, through its receptor DCC, inhibits RhoA in embryonic spinal commissural neurons. PMID: 18653556
    14. Data report that Bcl11A downregulates axon branching, and that the expression of DCC and MAP1b, two molecules involved in direction and branching of axon outgrowth, is controlled by Bcl11A-L. PMID: 19616629

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, DCC family
  • 組織特異性：
    Detected in embryonic spinal cord, predominantly in axons of commissural neurons (at protein level). Detected in embryonic spinal cord.
  • 數據庫鏈接：


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