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  4. Recombinant Rat NAD-dependent protein deacylase sirtuin-5, mitochondrial (Sirt5)

Recombinant Rat NAD-dependent protein deacylase sirtuin-5, mitochondrial (Sirt5)

  • 中文名稱：
    大鼠Sirt5重組蛋白
  • 貨號：
    CSB-YP715034RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Sirt5重組蛋白
  • 貨號：
    CSB-EP715034RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Sirt5重組蛋白
  • 貨號：
    CSB-EP715034RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Sirt5重組蛋白
  • 貨號：
    CSB-BP715034RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Sirt5重組蛋白
  • 貨號：
    CSB-MP715034RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Sirt5; NAD-dependent protein deacylase sirtuin-5; mitochondrial; EC 2.3.1.-; Regulatory protein SIR2 homolog 5; SIR2-like protein 5
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    37-310
  • 氨基酸序列
    SSNM ADFRKCFANA KHIVIISGAG VSAESGVPTF RGTGGYWRKW QAQHLATPLA FAHNPSQVWE FYHYRREVMR NKEPNPGHLA IAQCEARLRD QGRRVVVITQ NIDELHRKAG TKNLLEIHGT LFKTRCTSCG NVAENYKSPI CPALLGKGAP EPDTQESRIP VHKLPRCEEA GCGGLLRPHV VWFGENLDPA ILKEVDRELA RCDLCLVVGT SSVVYPAAMF APQVASRGVP VAEFNMETTP ATNRFRFHFP GPCGVTLPEA LAPHETERIS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
  • 基因功能參考文獻：
    1. Caloric restriction (CR) retarded declines in cognitive ability and enhanced the expression of both SIRT1 and SIRT5 proteins in the cerebral tissue of CR rats compared with AL rats PMID: 21826711
    2. Alcohol decreases mitochondrial SIRT5 level. PMID: 18555008
  • 亞細胞定位：
    Mitochondrion. Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    Sirtuin family, Class III subfamily
  • 數據庫鏈接：


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