在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Myelin-associated glycoprotein (Mag), partial

Recombinant Rat Myelin-associated glycoprotein (Mag), partial

  • 中文名稱：
    大鼠Mag重組蛋白
  • 貨號：
    CSB-YP013322RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Mag重組蛋白
  • 貨號：
    CSB-EP013322RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Mag重組蛋白
  • 貨號：
    CSB-EP013322RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Mag重組蛋白
  • 貨號：
    CSB-BP013322RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Mag重組蛋白
  • 貨號：
    CSB-MP013322RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Mag; Myelin-associated glycoprotein; 1B236; Brain neuron cytoplasmic protein 3; Sialic acid-binding Ig-like lectin 4a; Siglec-4a
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b.
  • 基因功能參考文獻：
    1. MAG, a RGD tri-peptide containing protein, forms a complex with beta1-integrin to mediate axonal growth cone turning responses of several neuronal types. PMID: 18922173
    2. only nucleotides 1315-1412 show ligand responsiveness to neurotrophin 3 (NT3) and myelin-associated glycoprotein (MAG) PMID: 20308067
    3. MAG inhibits regeneration by interaction with NgR. Binding of and inhibition by MAG are lost if neuronal GPI-linked proteins are cleaved. Binding of MAG to NgR-expressing cells is GPI dependent and sialic acid independent. PMID: 12160746
    4. Localisation within lipid rafts may provide a molecular environment that facilitates the interaction between MAG and multiple receptors and also between MAG ligands and molecules involved in signal transduction. PMID: 12691736
    5. induces phosphorylation of CRMP-2 in postnatal cerebellar neurons PMID: 16595691
    6. Exercise significantly decreased the levels of myelin-associated glycoprotein (MAG), a potent axonal growth inhibitor, suggesting that downregulation of MAG is part of the mechanism through which exercise reduces growth inhibition. PMID: 17497667
    7. Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells PMID: 17640868
    8. Our results suggest that MAG can inhibit the neuronal differentiation of neural progenitor cells PMID: 19349915

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 組織特異性：
    Detected in myelin. Detected in olfactory bulb and throughout the brain (at protein level). Detected in brain.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲v欧美v国产v在线观看| 国产精品美女一区二区视频| 两个人看的www在线观看| 欧美人与禽猛交狂配| 亚洲精品日本一区二区三区| 久久视频这里有精品33| 国产精品女同一区二区在线| 熟妇无码熟妇毛片| 亚洲愉拍自拍另类天堂| 亚洲综合久久一区二区| 老太婆性杂交视频| 色狠狠av一区二区三区| 真实国产精品vr专区| 高中生粉嫩无套第一次| 国产精品丝袜高跟鞋| 无码国内精品人妻少妇蜜桃视频| 天天噜日日噜狠狠噜免费 | 亚洲成av人片在线观看橙子| 欧美亚洲日韩不卡在线在线观看| 久久久国产乱子伦精品作者 | 欧美性xxxx极品少妇| 国产亚洲精品久久久性色情软件 | 国产下药迷倒白嫩美女网站 | 久久人人做人人爽人人av| 国产裸拍裸体视频在线观看| 少妇熟女高潮流白浆| 欧美性猛交xxxx黑人| 香蕉97超级碰碰碰视频| 亚洲人精品亚洲人成在线| 中文字幕日韩人妻在线视频| 中文在线а天堂中文在线新版| 国产精品亚洲精品日韩已满十八小| 九九热久久只有精品2| 欧美另类精品xxxx| 亚洲日韩aⅴ在线视频| 丰满少妇人妻久久久久久| 亚洲一卡2卡3卡4卡国产| 欧美成人性做爰77777| 中文字幕乱码熟女人妻水蜜桃| 久久综合久久鬼色| 亚洲大尺度无码无码专线|