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  4. Recombinant Rat Multidrug resistance-associated protein 1 (Abcc1), partial

Recombinant Rat Multidrug resistance-associated protein 1 (Abcc1), partial

  • 中文名稱：
    Recombinant Rat Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 貨號：
    CSB-YP804505RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 貨號：
    CSB-EP804505RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 貨號：
    CSB-EP804505RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 貨號：
    CSB-BP804505RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Multidrug resistance-associated protein 1(Abcc1) ,partial
  • 貨號：
    CSB-MP804505RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Abcc1; Mrp1; Multidrug resistance-associated protein 1; EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; EC 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.
  • 基因功能參考文獻：
    1. The ROS-mediated increase in the synthesis of MRP-1 and BCRP can play an important role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells. PMID: 28577929
    2. The data of this study show increased Abcc1, Abcc2, and Abcc4 mRNA expression at the BBB in response to H/R stress and that Abcc gene expression is regulated by Nrf2 signaling. PMID: 28298215
    3. MRP1 is downregulated in glioma cells by chitosan-MRP1 siRNA nanoparticles PMID: 25543328
    4. Sonication enhanced sensitivity of glioma tumor cells to doxorubicin by down-regulating the expressions of p-glycoprotein and multidrug resistance protein 1. PMID: 23940624
    5. The number of MRP1-positive cells in the cortex and hippocampus was also significantly increased in amygdale kindling rats. PMID: 23474709
    6. Xifeng Capsule used alone or combined with carbamazepine can effectively inhibit MRP1 expression in hippocampus and cortex of epileptic rats. PMID: 22883408
    7. Results show that the presence of Mdr1a, Mdr1b (P-glycoprotein Pgp) and multidrug resistance-associated protein (MRP1) encoding genes in the olfactory mucosa of rat and mouse was confirmed by RT-PCR. PMID: 22563480
    8. In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed. PMID: 22015764
    9. ATP-binding cassette ABCC1 is involved in the release of sphingosine 1-phosphate from rat uterine leiomyoma ELT3 cells and late pregnant rat myometrium PMID: 21803151
    10. increased activity of MRP1 in diabetic glomeruli is correlated with an inadequate adaptive response to oxidative stress PMID: 21495913
    11. down-regulation of Mrp1 protein at the blood-cerebrospinal fluid barrier may impact the Mrp1-mediated neuroprotective functions of the blood-cerebrospinal fluid barrier and actually potentiate UCB neurotoxicity PMID: 21297965
    12. Hepatic oval cells express high levels of MDR1, MRP1 and Bcrp1 genes which may have cytoprotective functions during severe hepatotoxicity. PMID: 17669244
    13. gp120 and TNF-alpha can up-regulate Mrp1 expression in cultured astrocytes. PMID: 20051532
    14. Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. PMID: 19897579
    15. MRP1 is involved in olfaction as a part of the "olfactory signal termination" by the chemical homeostasis in the "perireceptor events" of the olfactory epithelium. PMID: 19879335
    16. polyclonal antibodies recognizing both human and rodent MRP1 PMID: 11689020
    17. Mrp1 participates in the release of glutathione from astroglial cells PMID: 12125073
    18. MRP1 cDNA has been cloned, characterized and the transfected protein found capable of efflux transport of a fluorescent MRP1 marker--calcein--that is inhibitable by known MRP1 inhibitors, indomethacin, and MK571. PMID: 12423064
    19. The upregulation of Mrp1 in hemolysis is mediated by unconjugated bilirubin and/or other products of heme oxygenase,supporting a role of Mrp1 in transport and protection from its cellular toxicity. PMID: 14623264
    20. rat Abcc1 did not significantly confer cellular resistance to anthracyclins of vinca alkaloids. PMID: 14641820
    21. Mrp1 was rather expressed than P-gp in parenchyma astrocytes and in glia limitans lining the meninges. PMID: 15328029
    22. Transfection of lymphocytes with MRP1 gene completely abolished cyclopentenone prostaglandins (CP-PG) (0-40 microM) toxicity. Our findings suggest that CP-PG accumulation in lymphocytes may be, at least partially, responsible for cancer immunodeficiency. PMID: 16170839
    23. intrinsic higher capacity to express the MRP1/GS-X pump may dictate the redox status in the heart muscle PMID: 16868918
    24. The mRNA induction of MDR1, MRP1, MRP2 and MRP3 by rifampicin (Rif), dexamethasone (Dex) and omeprazole (Ome) was investigated in primary cultures of cryopreserved human and rat hepatocytes. PMID: 16946557
    25. Transport of sphingosine-1-phosphate by ABCC1 influenced migration of mast cells toward antigen but not degranulation PMID: 17050692
    26. These results point to a novel role of Mrp1 in the susceptibility of premature babies to UCB encephalopathy, and provide a startup point for the development of a new therapeutic strategy. PMID: 17141959
    27. The MRP1 gene is present in primary cultured rat epithelial cells of both types I- and II-like phenotypes and its corresponding protein is localized in the basolateral membrane of these cells. PMID: 17854063
    28. ABCB1, but not ABCC1, activity was downregulated in peripheral blood mononuclear cells and kidney of spontaneously hypertensive rats. PMID: 18057958
    29. Exposing prostatic tumor cell line to cell hypoxia reduced the Mrp1 activity by 24%. PMID: 18290326
    30. Increased molecular expression and functional activity of Mrp1 is demonstrated in an in vitro model of an HIV-associated pathological condition. PMID: 18485102
    31. MRP-1 transporter and efflux at skeletal muscles possibly play significant roles in statin-induced myopathy PMID: 18509883
    32. Results compare the relative amounts of ABCb1 (Pgp) and ABCc1 (Mrp1)at the blood-brain and blood-cerebrospinal fluid barriers, located respectively at the brain capillary endothelium and the choroid plexus epithelium. PMID: 18680196

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 組織特異性：
    Skeletal muscle, brain, heart, spleen, lung and kidney.
  • 數據庫鏈接：


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