在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Kinase D-interacting substrate of 220 kDa (Kidins220), partial

Recombinant Rat Kinase D-interacting substrate of 220 kDa (Kidins220), partial

  • 中文名稱：
    大鼠Kidins220重組蛋白
  • 貨號：
    CSB-YP872116RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Kidins220重組蛋白
  • 貨號：
    CSB-EP872116RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Kidins220重組蛋白
  • 貨號：
    CSB-EP872116RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Kidins220重組蛋白
  • 貨號：
    CSB-BP872116RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Kidins220重組蛋白
  • 貨號：
    CSB-MP872116RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Kidins220; Arms; Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.
  • 基因功能參考文獻：
    1. This work reveals a crucial physiological role of KIDINS220 in development and provides insight into how perturbation of the complex interplay of KIDINS220 isoforms and their relative expression can affect neuron control and human metabolism. Altogether, we here show that de novo protein-truncating KIDINS220 variants cause a new syndrome, SINO. This is the first report of KIDINS220 variants causing a human disease. PMID: 27005418
    2. overexpression of ARMS blocked NGF-mediated secretion, without affecting basal secretion, a decrease in ARMS resulted in potentiation. Similar effects were observed with synembryn-B, a protein that interacts directly with ARMS. Downstream of ARMS and synembryn-B are Galphaq and Trio proteins, which modulate the activity of Rac1 in response to NGF PMID: 26966186
    3. the existence of novel Kidins220/ARMS splice isoforms with unique properties PMID: 26083449
    4. a novel partner of Kidins220/ARMS PMID: 22609016
    5. findings show that Kidins220/ARMS is a novel component of the uropod involved in the regulation of T-cell motility, an essential process for the immune response PMID: 21381019
    6. A decrease in ARMS/Kidins220 levels suppressed GABAergic neurotransmission; overexpression of ARMS/Kidins220 produced an increase in GABAergic neurotransmission in hippocampal neurons; ARMS/Kidins220 regulates GABAergic neurotransmission presynaptically. PMID: 20936698
    7. the levels of ARMS/Kidins220 can be regulated by neuronal activity and calpain action to influence synaptic function. PMID: 20943655
    8. The direct interaction between ARMS/Kidins220 and Sept5 suggests a possible role of ARMS/Kidins220 as a functional link between neurotrophin receptors and septins to mediate neurotrophin-induced intracellular signaling events. PMID: 20680483
    9. Kidins220 regulates Rac1-dependent neurite outgrowth by direct interaction with the Trio. PMID: 20519585
    10. Altogether, our findings suggest that ARMS may play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EphA4. PMID: 15939763
    11. Kidins220/ARMS-positive carriers undergo a kinesin-1-dependent transport linked to neurotrophin action. PMID: 17079733
    12. Kidins220/ARMS participation in neuronal life and death pathways. PMID: 19759287

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Late endosome. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.
  • 組織特異性：
    Expressed in developing nervous system and in highly plastic areas of the adult brain. Also expressed in neuroendocrine cells, where it concentrates at the tip of neurites. Expressed in developing muscle and is concentrated at the neuromuscular junction (
  • 數據庫鏈接：


主站蜘蛛池模板： 久久香综合精品久久伊人| 婷婷综合另类小说色区| 亚洲色欲久久久久综合网| 国产成人片无码免费视频| 久久久久国色av∨免费看| 浴室人妻的情欲hd三级国产 | 久久精品天天中文字幕人妻| 色妞精品av一区二区三区| 日本高清在线www3344| 护士被强女千到高潮视频| 国产欠欠欠18一区二区| 国内精品久久久久久影院| 2018年秋霞无码片| 色一情一乱一乱一区99av白浆| 全部免费毛片在线播放| 在线观看一区二区三区国产免费| 日韩国产亚洲一区二区三区| 青青草免费公开视频| 伊人久久大香线蕉av一区二区| 六月丁香综合在线视频| 午夜精品影视国产一区在线麻豆| 两口子交换真实刺激高潮| 欧美人与动欧交视频| 精品国产一区二区三区av孞弋| 国产精品亚洲欧美中字| 失禁大喷潮在线播放| 97国产精品麻豆性色aⅴ人妻波| 四虎国产精品永久地址入口| 精品无码av无码免费专区| 天天躁日日躁狠狠很躁| 2020年最新国产精品正在播放| 18禁成人黄网站免费观看久久 | 深夜爽爽动态图无遮无挡| 欧美饥渴熟妇高潮喷水水| 国产无线乱码一区二三区| 色先锋影音岛国av资源| 被灌满精子的波多野结衣| 插插无码视频大全不卡网站| 色猫咪免费人成网站在线观看| 在线日韩av免费永久观看| 好男人www社区|