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  4. Recombinant Rat Insulin-like growth factor-binding protein 5 (Igfbp5)

Recombinant Rat Insulin-like growth factor-binding protein 5 (Igfbp5)

  • 中文名稱：
    大鼠Igfbp5重組蛋白
  • 貨號：
    CSB-YP011099RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Igfbp5重組蛋白
  • 貨號：
    CSB-EP011099RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Igfbp5重組蛋白
  • 貨號：
    CSB-EP011099RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Igfbp5重組蛋白
  • 貨號：
    CSB-BP011099RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Igfbp5重組蛋白
  • 貨號：
    CSB-MP011099RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Igfbp5; Igfbp-5; Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    20-271
  • 氨基酸序列
    L GSFVHCEPCD EKALSMCPPS PLGCELVKEP GCGCCMTCAL AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL NEKSYGEQTK IERDSREHEE PTTSEMAEET YSPKVFRPKH TRISELKAEA VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP EMRQESDQGP CRRHMEASLQ EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC WCVDKYGMKL PGMEYVDGDF QCHAFDSSNV E
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻：
    1. Insulin growth factor binding protein 5 (IGFBP-5), insulin growth factor (IGF-1) and transforming growth factor (TGF-beta1) in the type II alveolar epithelial cells (AECs) play a key role in lung injury caused by bleomycin and pioglitazone attenuates the lung injury/fibrosis by restoring IGFBP-5 and IGF-1 and decreasing TGF-beta1 expressions in the type II AECs. PMID: 28077319
    2. Silencing IGFBP5 with small interfering RNA significantly reduced apoptosis and suppressed the expression of caspase3 in neonatal rat ventricular myocytes following treatment with methamphetamine. PMID: 25230843
    3. IGFBP5 expression was up-regulated in the striatum of methamphetamine exposed male Sprague-Dawley rats. PMID: 25127757
    4. IGFBP5 mediates high glucose-induced cardiac fibroblast activation PMID: 23417767
    5. IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation. PMID: 21598309
    6. Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A. PMID: 20167606
    7. Downregulation of IGFBP-5 gene expression may cause pulmonary hypoplasia in the nitrofen-induced CDH model by interfering with retinoid signaling pathway. PMID: 19844724
    8. Chronic exposure to high glucose leads to impaired mesangial cell migration in response to IGFBP-5 as a result of loss of laminin beta2 protein. PMID: 19864299
    9. plays an important role in the development of the anterior pituitary gland PMID: 12006713
    10. findings indicate that the modulation of rat ovarian insulin-like growth factor binding protein-4 and -5 is protein kinase C as well as protein kinase A dependent PMID: 12193414
    11. IGFBP-3 and -5 proteins may have potential modulatory roles in type I fiber-dominated muscles, aging, and regrowth from atrophy. PMID: 12397024
    12. Specific amino acid substitutions determine the differential contribution of the N- and C-terminal domains of insulin-like growth factor (IGF)-binding protein-5 in binding IGF-I PMID: 12626499
    13. Overexpression of rat IGFBP-5 in transduced murine MC3T3 osteoblasts decreases osteoblastic function possibly by binding insulin-like growth factors in the bone microenvironment. PMID: 15589207
    14. IGF-I uses different and only partially overlapping intracellular signaling pathways for regulation of IGFBP-3 and -5 with opposing biological functions might be important for modulation of IGF bioactivity in cellular microenvironment. PMID: 15845624
    15. Although IGFBP-5 overexpression did not have an IGF-independent effect on RCJ cell differentiation, it promoted IGF-I-enhanced differentiation of these cells. PMID: 16204335
    16. Inflammatory insults decrease muscle IGFBP-5 mRNA by a TNF-dependent glucocorticoid-independent mechanism. IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions. PMID: 16339387
    17. Unique function for the laminin-9 complex in mediating IGFBP-5-induced migration. PMID: 16672690

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Mostly in kidney.
  • 數據庫鏈接：


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