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  4. Recombinant Rat Insulin-like 3 (Insl3), partial

Recombinant Rat Insulin-like 3 (Insl3), partial

  • 中文名稱：
    大鼠Insl3重組蛋白
  • 貨號：
    CSB-YP895287RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Insl3重組蛋白
  • 貨號：
    CSB-EP895287RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Insl3重組蛋白
  • 貨號：
    CSB-EP895287RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Insl3重組蛋白
  • 貨號：
    CSB-BP895287RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Insl3重組蛋白
  • 貨號：
    CSB-MP895287RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Insl3
  • Uniprot No.：
  • 別名：
    Insl3; Rlf; Insulin-like 3; Leydig insulin-like peptide; Ley-I-L; Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 表達區域：
    -
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
  • 基因功能參考文獻：
    1. The observed postnatal difference in gubernacular malformations between two rate strains is due to different levels of the insl3 receptor differ among strains. PMID: 21633115
    2. data suggest that INSL3 signaling in fetal gubernaculum induces morphogenetic programs in male genitalia; investigation of differences in gene expression regulation by INSL3 in gubernaculum of male and female genitalia PMID: 20631401
    3. Demonstration of INSL3 as the ligand for LGR8 facilitates understanding of the mechanism of testis descent and allows studies on the role of INSL3 in gonadal and other physiological processes PMID: 12114498
    4. Rat leucine-rich repeat-containing G protein-coupled receptor 8 bound INSL3 with high affinity, clearly demonstrating that it is the rat INSL3 receptor PMID: 15956681
    5. INSL3/leucine-rich repeat-containing G protein-coupled receptor 8 signaling may be involved in the genesis and/or developmental maturation of renal glomeruli PMID: 15956754
    6. Prenatal mono-n-butyl phthlate may inhibit the INSL3 gene expression associated with the transabdominal testicular ascent in fetal rats, thereby causing undescended testis in postnatal offspring PMID: 16338306
    7. In utero exposure to flutamide decreases expression levels of Insl3 particularly at 15 days post conception. PMID: 18772241
    8. INSL3 evidently traverses the blood-testis barrier to enter the seminiferous compartment, rete testis, and epididymis in sufficient concentration to be able to address the specific INSL3 receptors (RXFP2) on post-meiotic germ cells and in the epididymis. PMID: 19420383
    9. Prenatal exposure to diaethylstilbestrol can inhibit transabdominal testicular descent via down-regulating the expression of INSL3, which is induced by down-regulating the expression of SF-1. PMID: 19493424

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Insulin family
  • 組織特異性：
    Expressed in Leydig cells of the testis, and weakly in the theca interna cells of antral follicles and the corpus luteum of the ovary.
  • 數據庫鏈接：


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