在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Histamine H1 receptor (Hrh1), partial

In Stock
  • 中文名稱:
    大鼠Hrh1重組蛋白
  • 貨號:
    CSB-EP010737RA1
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    (H1R)(HH1R)
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    30.6 kDa
  • 表達區域:
    211-415aa
  • 氨基酸序列
    VKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
  • 基因功能參考文獻:
    1. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons. PMID: 28722302
    2. findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission. PMID: 28964277
    3. This study demonstrates that AITC-induced nociception in vivo depends on TRPA1 and is decreased by the blockade of the NK1 receptor for SP, the H1 receptor for histamine and the 5-HT1A and 3 receptors for 5-HT PMID: 27904941
    4. An H1 receptor blocker did not affect exercise-induced improvement in learning and memory in rats, so these receptors may not play a role in this process. PMID: 25192644
    5. Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-muM histamine. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine. PMID: 24702851
    6. Activation of H1R was required dopaminergic lineage during ventral midbrain development. PMID: 25112718
    7. Na+-Ca2+ exchangers coupled to H1 receptors and hyperpolarization-activated cyclic nucleotide-gated channels linked to H2 receptors co-mediate the strong postsynaptic excitatory action of histamine on al vestibular nucleus neurons PMID: 23713466
    8. These results show that histamine, by activating H(1)R, has a neurogenic effect in clonal conditions PMID: 23497494
    9. Histamine within the nucleus tractus solitarii may play a role in regulating cardiovascular homeostasis via activation of H1 receptors. PMID: 21622829
    10. at the level of the hippocampus, histamine through its H1 and H2 receptors, mediates orofacial region pain PMID: 21602597
    11. H1 receptors play an excitatory role in the modulation of the discharge activities of the inspiratory neurons in neonatal rat brainstem slices. PMID: 20117984
    12. Based on its ability to reverse amphetamine-induced PPI deficits, blockade of histamine H(1) receptors seems to contribute to the therapeutic effect of the antipsychotic clozapine. PMID: 20811878
    13. Studies using various antagonists indicate hippocampal Hrh1 plays an important role in encoding, retention, and retrieval processes of spatial working memory. PMID: 20096284
    14. Activation of H1-receptors in vasopressinergic neurons results in downstream activation of NO synthase, which then mediates the H1-receptor effects. PMID: 12419527
    15. ThEA stimulation evoked amylase release via H1 receptor but was not followed by L-arginine/nitric oxide pathway activation. PMID: 12581497
    16. H1, H2, and H3 histamine receptor mRNA detected in modiolus but not in lateral and medial portions of the cochlea. First evidence of H1, H2, and H3 histamine receptor mRNA in rat cochlea. PMID: 12634496
    17. histamine H(1)-receptor and PKC are involved in the signal transduction pathway, responsible for histamine-stimulated NGF secretion from cultured astrocytes PMID: 15167971
    18. In rat thalamus, histamine H(1) receptor and isoforms of H(3) receptor were expressed predominantly in the midline and intralaminar areas PMID: 15899242
    19. Postischemic increase in H(1) receptor mRNA expression in the caudate-putamen. PMID: 16181737
    20. data represent the first demonstration of H1 receptor expression in sympathetic preganglionic neurons and suggest that histamine acts to regulate excitability of these neurons via a direct postsynaptic effect on H1 receptors PMID: 16354729
    21. Processing of proprioceptive information at the level of the mesencephalic trigeminal neurons is controlled via histamine H1 and H3 receptors through different postsynaptic mechanisms. PMID: 16797837
    22. Results suggest that hippocampal H1 receptors play an important role in working memory processes on radial maze performance and the decrease in hippocampal theta power is associated with the working memory deficit induced by the blocking of H1 receptors. PMID: 17562388
    23. Data show that the synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via a H1-receptor-PKC-MAPK signalling pathway. PMID: 18345501
    24. Data show that cetirizine, a histamine H1 receptor antagonist, decreases the first stage of orthodontic tooth movement in rats. PMID: 18345503
    25. The expression of H1 receptor mRNA was up-regulated in the hypothalamus and brainstem, but not in the cerebral cortex after 2 G hypergravity load in rats. PMID: 18607976
    26. These results suggest that chewing-induced histamine release in the hippocampus and the subsequent H1 receptor activation may be essential to rescue stress-suppressed synaptic plasticity. PMID: 19393269

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:


主站蜘蛛池模板: 水蜜桃精品一二三| 国产98在线 | 免费、| 亚洲欧美另类久久久精品| 国产另类ts人妖一区二区| 欧美黑人又粗又硬xxxxx喷水| 中文字幕精品亚洲无线码vr| 顶级少妇做爰视频在线观看| www国产亚洲精品| 亚洲真人无码永久在线| 超清制服丝袜无码av福利网| 五月综合激情婷婷六月色窝| 无码av高潮抽搐流白浆| 久久超碰精品一夜七次郎| 久久综合久久爱久久综合伊人| 日本高清一区二区三| 久久久国产一区二区三区四区小说 | 欧美性videos高清精品| 色欲天天网站欧美成人福利网| 成人做爰视频www网站| 国产欧美精品一区二区色综合| 国产精品久久久久久妇女6080| 2021精品国夜夜天天拍拍| 久久欧美一区二区三区性牲奴| 亚洲一区二区三区尿失禁| 蜜臀aⅴ国产精品久久久国产老师| 国产精品久久无码不卡黑寡妇 | 无码天堂亚洲国产av麻豆| 色琪琪av中文字幕一区二区| 欧美激情视频一区二区三区免费| 亚洲精品国精品久久99热| 爆乳护士一区二区三区在线播放 | 国产成年码av片在线观看| 欧美大屁股熟妇bbbbbb| 99精品国产在热久久婷婷| 中文字幕熟妇人妻在线视频| 久久精品中文字幕第一页| 欧美成人一区二区三区在线观看 | 东方aⅴ免费观看久久av| 亚洲卡一卡二卡三新区乱码| 最新国产在线拍揄自揄视频| 色综合视频一区二区三区|