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  4. Recombinant Rat Hepatocyte nuclear factor 3-beta (Foxa2)

Recombinant Rat Hepatocyte nuclear factor 3-beta (Foxa2)

  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-YP008795RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-EP008795RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-EP008795RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-BP008795RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-MP008795RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Foxa2; Hnf3b; Tcf-3b; Tcf3bHepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-458
  • 氨基酸序列
    MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNASLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM SGSAGAAGVA GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDFLKVP RAPDKPGKGS FWTLHPDSGN MFENGCYLRR QKRFKCENEL ALKEAAGAGS GGGKKTAPGT QASQVQLGEA AGSASETPAG TESPHSSASP CQEHKRGGLS ELKGTPASAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKTYEQVMH YPGGYGSPMP GSLAMGPVTN KAGLDASPLA ADTSYYQGVY SRPIMNSS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Acts synergistically with ONECUT1 to activate transcription of female-specific CYP2C12; the function is inhibited by growth hormone-activated STAT5B. Acts synergistically with HNF4A to activate transcription of APOA1.
  • 基因功能參考文獻：
    1. MAPK and FoxA2 mediate CS-induced squamous metaplasia. MAPK inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia. PMID: 29200841
    2. HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney. PMID: 24157454
    3. Sumoylation increased the transcriptional activity of FOXA2. PMID: 23118920
    4. IL-13 down-regulates mucus secretion via STAT6-FOXA2 pathway in vitro. PMID: 21269961
    5. Data demonstrate that FoxA2 could dynamically regulate FoxO1 and PDX-1 expression in pancreatic beta-cells treated with DEX. PMID: 21385937
    6. increased expression of HNF3beta modestly reduces viral transcription and dramatically inhibits replication in vivo in the HBV transgenic mice. PMID: 12438623
    7. Reduced FoxA2 may be important in the suppression of protein C in a rat cecal ligation and puncture (CLP) model of polymicrobial sepsis. PMID: 16522789
    8. The results presented here show that Foxa2 and USFs regulate the distal promoter of the rat PC gene in a cell-specific manner. PMID: 17408383
    9. The overexpression of the SLC2A2 gene in the kidney of diabetic rats is associated with the transcriptional activity of HNF-1alpha and HNF-3beta. PMID: 19433262
    10. Phosphorylation of FoxA2 by DNA-dependent protein kinase modulates its transcriptional activation potential. PMID: 19478084

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
  • 組織特異性：
    Liver.
  • 數據庫鏈接：


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