在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Hepatocyte nuclear factor 3-beta (Foxa2)

Recombinant Rat Hepatocyte nuclear factor 3-beta (Foxa2)

  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-YP008795RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-EP008795RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-EP008795RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-BP008795RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Foxa2重組蛋白
  • 貨號：
    CSB-MP008795RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Foxa2; Hnf3b; Tcf-3b; Tcf3bHepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-458
  • 氨基酸序列
    MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNASLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM SGSAGAAGVA GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDFLKVP RAPDKPGKGS FWTLHPDSGN MFENGCYLRR QKRFKCENEL ALKEAAGAGS GGGKKTAPGT QASQVQLGEA AGSASETPAG TESPHSSASP CQEHKRGGLS ELKGTPASAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKTYEQVMH YPGGYGSPMP GSLAMGPVTN KAGLDASPLA ADTSYYQGVY SRPIMNSS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Acts synergistically with ONECUT1 to activate transcription of female-specific CYP2C12; the function is inhibited by growth hormone-activated STAT5B. Acts synergistically with HNF4A to activate transcription of APOA1.
  • 基因功能參考文獻：
    1. MAPK and FoxA2 mediate CS-induced squamous metaplasia. MAPK inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia. PMID: 29200841
    2. HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney. PMID: 24157454
    3. Sumoylation increased the transcriptional activity of FOXA2. PMID: 23118920
    4. IL-13 down-regulates mucus secretion via STAT6-FOXA2 pathway in vitro. PMID: 21269961
    5. Data demonstrate that FoxA2 could dynamically regulate FoxO1 and PDX-1 expression in pancreatic beta-cells treated with DEX. PMID: 21385937
    6. increased expression of HNF3beta modestly reduces viral transcription and dramatically inhibits replication in vivo in the HBV transgenic mice. PMID: 12438623
    7. Reduced FoxA2 may be important in the suppression of protein C in a rat cecal ligation and puncture (CLP) model of polymicrobial sepsis. PMID: 16522789
    8. The results presented here show that Foxa2 and USFs regulate the distal promoter of the rat PC gene in a cell-specific manner. PMID: 17408383
    9. The overexpression of the SLC2A2 gene in the kidney of diabetic rats is associated with the transcriptional activity of HNF-1alpha and HNF-3beta. PMID: 19433262
    10. Phosphorylation of FoxA2 by DNA-dependent protein kinase modulates its transcriptional activation potential. PMID: 19478084

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
  • 組織特異性：
    Liver.
  • 數據庫鏈接：


主站蜘蛛池模板： 最新永久无码av网址亚洲| 在线视频网站www色| 国产精品久久久久久妇女| 久久人人97超碰国产亚洲人 | 激情综合色综合啪啪五月丁香搜索 | 中文字幕乱码一区二区三区免费| 欧美日本特级婬片视频| 亚洲小说春色综合另类| 欧美性受xxxx黑人xyx性爽 | 潮喷失禁大喷水无码| 成人av在线一区二区三区| 一区二区三区在线 | 日| 免费中文熟妇在线影片| 人妻aⅴ中文字幕| 国产在不卡免费一区二区三| 97丨九色丨国产人妻熟女| 国产成人无码av在线播放dvd| 四虎一区二区成人免费影院网址 | 四虎成人精品一区二区免费网站| 巨胸不知火舞露双奶头无遮挡| 免费毛片a线观看| 2020久久超碰国产精品最新| 欧洲成人午夜精品无码区久久| 国产毛a片啊久久久久久保和丸| 浪荡女天天不停挨cao日常视频| 无码帝国www无码专区色综合 | 精品毛片乱码1区2区3区| 国产精品自在在线午夜免费| 胸大美女又黄的网站| 不卡无码av一区二区三区| 亚洲最大无码中文字幕网站| 性按摩玩人妻hd中文字幕| 伊人色综合久久天天| 香蕉97超级碰碰碰视频| 被灌满精子的波多野结衣| 国产麻豆成人精品av| 2020精品国产午夜福利在线观看| 亚洲欧美黑人深喉猛交群| 久久成人影院精品777| 久久九九兔免费精品6| 国产精品久久久久影院亚瑟|