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  4. Recombinant Rat Hepatocyte growth factor receptor (Met), partial

Recombinant Rat Hepatocyte growth factor receptor (Met), partial

  • 中文名稱：
    大鼠Met重組蛋白
  • 貨號：
    CSB-YP013714RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Met重組蛋白
  • 貨號：
    CSB-EP013714RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Met重組蛋白
  • 貨號：
    CSB-EP013714RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Met重組蛋白
  • 貨號：
    CSB-BP013714RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Met重組蛋白
  • 貨號：
    CSB-MP013714RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MetHepatocyte growth factor receptor; HGF receptor; EC 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.
  • 基因功能參考文獻：
    1. transplantation of c-Met-bone marrow-derived mesenchymal stem cells (BMSCs) ameliorated liver injury with reduced hepatic activity index (HAI) scores, and that the effects of c-Met-BMSCs were more profound than those of control BMSCs. PMID: 28679425
    2. Met was strongly expressed in BASCs, which expressed an AT2 cell marker, pro-SP-C, and a club cell marker, CCSP. PMID: 26972715
    3. The dynamic expression and localization of different c-MET isoforms in the rat pancreas during different developmental stages indicates that distinct c-MET isoform might be involved in different aspects of pancreatic development PMID: 25674220
    4. miR-210 over-expression improves MSC survival under oxidative stress through antioxidation and c-Met pathway activation PMID: 25168379
    5. Phosphorylation of Met-Ser985 in hepatocytes plays a regulatory role in Met activation in response to quiescence, injury, and regeneration. PMID: 23618918
    6. KRC-408 is a novel therapeutic candidate effective against gastric cancers that overexpress c-Met, inhibiting cell proliferation and angiogenesis. PMID: 23348694
    7. c-Met expression in ipsilateral L4-L5 DRGs and within the ipsilateral dorsal horn was found to be significantly up-regulated following sciatic nerve ligation, from day 5 to day 14, with peak levels of expression detected on days 7 and 14. PMID: 20814222
    8. This study demonstrates that the sole oncogenic engagement of Met receptor in normal intestinal epithelial cells is sufficient to induce cancerous biological processes that are fundamental to the initiation and progression of colorectal cancers. PMID: 20539003
    9. Transfection of phosphatidylethanolamine N-methyltransferase 2 gene causes decreased autophosphorylation of c-Met. PMID: 16867273
    10. c-Met-IR in postmitotic neurons as well as in neuroepithelial cells PMID: 12106690
    11. HGF receptor, c-met, is end xpressed in testicular and epididymal spermatozoa, exclusively localized on the head in testicular sperm. A different localization in sperm isolated from caput and cauda epididymidis. PMID: 12399538
    12. c-Met is involved in the liver invasive phenotype of adult T-cell leukemia PMID: 12538467
    13. Cytokines regulate expression of this protein in cultured astrocytes. PMID: 12543460
    14. Microarray analysis and RNA silencing link fra-1 to the expression of cd44 and this protein in mesothelioma. PMID: 12839939
    15. significant increase in Met docking site activity in both renal medulla and cortex solely following stimulation by ischaemia and repair PMID: 12897086
    16. Hgfr signaling mediates the anti-fibrotic action of alitretinoin in glomerular mesangial cells. PMID: 16192631
    17. growth factor enriched extracellular milieu and loss of intact liver architecture seems to be accompanied by an up-regulation of c-Met surface level PMID: 16465395
    18. Data suggest that intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated Met-beta-catenin dissociation, beta-catenin translocation, activation and mitogenesis. PMID: 16952352
    19. Induction (or enhancement) of the endogenous HGF/c-met axis in the kidney is in part responsible for hepatectomy-mediated renal protection in glycerol-induced actue kidney injury. PMID: 17940345

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 組織特異性：
    Expressed at highest levels in lung, liver and kidney, also expressed in stomach, intestine, spleen, testis and brain. Not expressed in heart or muscle.
  • 數據庫鏈接：


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