在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Hepatitis A virus cellular receptor 2 homolog (Havcr2), partial

  • 中文名稱:
    大鼠Havcr2重組蛋白
  • 貨號(hào):
    CSB-YP010145RA
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Havcr2重組蛋白
  • 貨號(hào):
    CSB-EP010145RA
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Havcr2重組蛋白
  • 貨號(hào):
    CSB-EP010145RA-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Havcr2重組蛋白
  • 貨號(hào):
    CSB-BP010145RA
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Havcr2重組蛋白
  • 貨號(hào):
    CSB-MP010145RA
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Havcr2; Tim3; Timd3; Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3; CD antigen CD366
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    Partial
  • 表達(dá)區(qū)域:
    22-194
  • 氨基酸序列
    LENAYTAEVGKNAYLPCSYTVPAPGTLVPICWGKGSCPLLQCASVVLRTDETNVTYRKSRRYQLKGNFYKGDMSLTIKNVTLADSGTYCCRIQFPGPMNDEKLELKLSITEPAKVIPAGTAHGDSTTASPRTLTTEGSGSETQTLVTLHDNNGTKISTWADEIKDSGETIRTA
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits. In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN. Expressed on Treg cells can inhibit Th17 cell responses. Receptor for LGALS9. Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth. However, the function as receptor for LGALS9 has been challenged. Also reported to enhance CD8+ T cell responses to an acute infection such as by Listeria monocytogenes. Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes. Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13. Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9. In contrast, shown to suppress NK cell-mediated cytotoxicity. Negatively regulates NK cell function in LPS-induced endotoxic shock.
  • 基因功能參考文獻(xiàn):
    1. we show that the galectin-9/Tim-3 cell signaling pathway is involved in inflammation induced by stroke PMID: 24771108
    2. Tim3(+) cells might include a distinct macrophage population, which may be involved in anti-inflammatory effect and recovery from experimental autoimmune neuritis PMID: 21784136
  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein. Cell junction.
  • 蛋白家族:
    Immunoglobulin superfamily, TIM family
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 人妻丰满熟妇av无码处处不卡| 婷婷四房色播| 国产精品久久自在自线青柠| 男人和女人高潮做爰视频| 99热在线精品免费全部my| 国产精品18禁污污网站| 久久99精品久久久大学生| www国产内插视频| 77777五月色婷婷丁香视频| 国产69精品久久久久孕妇| 乌克兰少妇xxxx做受| 亚洲乱码日产精品bd在线观看 | 国产高清视频在线观看69| 国产精品禁18久久久夂久| 国产亚洲产品影市在线产品| 人人做人人爽人人爱| 日本一区二区a√成人片| 国产综合18久久久久久| 性欧美vr高清极品| 国产精品无码一区二区三区 | 国产精品国产成人国产三级| 久久综合色_综合色88| 一本无码人妻在中文字幕| 亚洲日韩中文字幕一区| 欧美日韩无套内射另类| 国产成人愉拍免费视频| 人人超人人超碰超国产97超碰| 人妻另类 专区 欧美 制服| 国产成人无码午夜福利在线直播| 2019国产品在线视频| 2019nv天堂香蕉在线观看| 极品少妇被黑人白浆直流| 超碰97人人让你爽| 熟女人妻视频| 亚洲精品一区国产欧美| 色综合欧美五月俺也去| 狠狠色狠狠色综合网| 亚洲国产成人久久一区二区三区 | 国产精品白丝喷浆| 久久久久国产精品人妻aⅴ果冻| 欧美日韩精品人妻狠狠躁免费视频|