在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Heat shock protein HSP 90-beta (Hsp90ab1)

  • 中文名稱:
    大鼠Hsp90ab1重組蛋白
  • 貨號:
    CSB-YP010808RA
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Hsp90ab1重組蛋白
  • 貨號:
    CSB-EP010808RA
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Hsp90ab1重組蛋白
  • 貨號:
    CSB-EP010808RA-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Hsp90ab1重組蛋白
  • 貨號:
    CSB-BP010808RA
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Hsp90ab1重組蛋白
  • 貨號:
    CSB-MP010808RA
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Hsp90ab1; Hsp84; Hspcb; Heat shock protein HSP 90-beta; Heat shock 84 kDa; HSP 84; HSP84
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-724
  • 氨基酸序列
    PEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN DDEQYAWESS AGGSFTVRAD HGEPIGRGTK VILHLKEDQT EYLEERRVKE VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKEDEEKPKI EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK NNIKLYVRRV FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI LKVIRKNIVK KCLELFSELA EDKENYKKFY EAFSKNLKLG IHEDSTNRRR LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES KEQVANSAFV ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA VKDLVVLLFE TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVTAEEP SAAVPDEIPP LEGDEDASRM EEVD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10.
  • 基因功能參考文獻:
    1. Hsp90beta inhibition caused the destabilization of upstream mediators in various pathogenic signalling events, thereby effectively ameliorating this nephropathy owing to renal hypoxia and oxidative stress. PMID: 27248656
    2. mRNA expression levels of heat shock proteins HSP27, HSP70, HSP84 in the soleus muscle were inhibited by hindlimb suspension & spaceflight; mRNA expression levels of the HSPs in the plantaris muscle did not change after hindlimb suspension. PMID: 18845059
    3. The Hsp90 beta reduced significantly NO(2)/NO(3) and increased O(2)(-) generation. PMID: 21063103
    4. The antiapoptotic activity of Bcl-2 was greatly affected by knocking-out specifically Hsp90beta using the RNA interference approach. PMID: 16166581
    5. Data show that morphine differentially regulates hsp90beta expression in the nucleus accumbens of Lewis and Fischer 344 rats. PMID: 17562399
    6. results indicate geldanamycin exerts its regulatory effects through transcription elements including heat-shock elements, boxes and TATA boxes, resulting in differential transactivation of hsp90alpha and hsp90beta in rat gliosarcoma 9L cells PMID: 18320580

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Melanosome. Nucleus. Secreted. Cell membrane. Dynein axonemal particle.
  • 蛋白家族:
    Heat shock protein 90 family
  • 數據庫鏈接:


主站蜘蛛池模板: 人妻少妇精品视中文字幕国语| 无码人妻丰满熟妇区免费 | 精品国产丝袜自在线拍国语| 久久精品日日躁夜夜躁| 国产日韩av在线播放| 蜜臀av人妻国产精品建身房| 国内精品久久久久久久久电影网| 国产男女猛烈视频在线观看| 毛片内射-百度| 无码成人aaaaa毛片| 久久成人国产精品免费| 爆乳一区二区三区无码| 麻豆md0077饥渴少妇| 一 级做人爱全视频在线看| 国产在线精品无码不卡手机免费| 成人av片在线观看免费| 精品乱人伦一区二区三区| 亚洲国产成人一区二区在线| 久久人人97超碰爱香蕉| 西西人体www44rt大胆高清| 国产精品久久久久久超碰| 亚洲国产成人av在线观看| 免费看撕开奶罩揉吮奶头视频| 好爽好舒服要高潮了视频| 国产精品一品二区三区的使用体验| 天干夜啦天干天干国产免费| 日韩精品一卡2卡3卡4卡新区 | 久久天天躁狠狠躁夜夜96流白浆| 波多野结衣不打码视频| 无码人妻丰满熟妇精品区| 涩里番网污站| 国产成人精品免高潮在线观看| 狠狠色噜噜狠狠狠狠777米奇| 婷婷五月日韩av永久免费| 国产精品爽爽va吃奶在线观看| 色77久久综合网| 亚洲精品国产av成拍色拍个| 邪恶肉肉全彩色无遮盖| 久久人人玩人妻潮喷内射人人| 人人鲁人人莫人人爱精品| 久久综合精品国产一区二区三区无码 |