在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Glutamate receptor 4 (Gria4), partial

  • 中文名稱:
    大鼠Gria4重組蛋白
  • 貨號:
    CSB-YP009901RA
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Gria4重組蛋白
  • 貨號:
    CSB-EP009901RA
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Gria4重組蛋白
  • 貨號:
    CSB-EP009901RA-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Gria4重組蛋白
  • 貨號:
    CSB-BP009901RA
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Gria4重組蛋白
  • 貨號:
    CSB-MP009901RA
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Gria4; Glur4; Glutamate receptor 4; GluR-4; GluR4; AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic; AMPA 4; GluA4
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
  • 基因功能參考文獻:
    1. Data show that PKA activation leads to insertion of GluA4 to synaptic sites with initially weak or silent AMPAR-mediated transmission. This suggests that the GluA4-mediated activation of silent synapses is a critical mechanism facilitating the functional maturation of glutamatergic circuitry during the critical period of experience-dependent fine-tuning. PMID: 27157711
    2. Several interactors of GluR4 AMPA receptor subunit were id'd, most of which are novel AMPA receptor partners, namely, cytoskeleton proteins, motor proteins, RNA processing proteins which are part of neuronal RNA granules, and kinases, among others. PMID: 20131911
    3. examination of the ligand-binding properties of homomeric GluR-D and its soluble ligand-binding domain with mutations at these positions PMID: 12473122
    4. Following retinal ischemia-reperfusion, immunoreactivity of GluR4 is confined to the plexiform layers and a punctate labeling located in the outer nuclear layer. PMID: 14706873
    5. Two complexes of the GluR4 receptor ligand-binding domain have been crystallized (with full and partial agonists) that will provide insights into the detailed agonist-binding stereochemistry of this physiologically important neurotransmitter receptor. PMID: 18765917
    6. Our results also provide the first evidence that postsynaptic GluR4-containing AMPA receptors are involved in spinal nociceptive transmission. PMID: 19052206
    7. the GluR4 subunit exhibits a different correlation between receptor activation and ligand-binding domain cleft closure than does GluR2 PMID: 19102704

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression.
  • 蛋白家族:
    Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA4 subfamily
  • 組織特異性:
    Detected in cerebellum (at protein level).
  • 數據庫鏈接:


主站蜘蛛池模板: 伊人99综合精品视频| 国产精自产拍在线看中文| 亚洲中文字幕乱码av波多ji| 欧美成aⅴ人高清免费观看| 人妻丰满熟av无码区hd| 最新亚洲人成网站在线观看| 超碰香蕉人人网99精品| 一本aⅴ高清一区二区三区| 国产成人精品无码a区在线观看| 日韩一区二区a片免费观看| 国产69久久精品成人看| 成人毛片av免费| 无码午夜福利免费区久久| 图片小说视频一区二区| 2017亚洲天堂最新地址| 天堂网www最新版官网| 亚洲性猛交xxxx| 性欧美激情aa片在线播放| 免费人成在线观看成人片| 2020精品国产自在现线官网| 一本一道人人妻人人妻αv| 久精品国产欧美亚洲色aⅴ大片| 日韩免费无码视频一区二区三区 | 午夜无码性爽快影院6080| 亚洲欧洲日韩综合久久| 激情五月综合色婷婷一区二区| 亚洲精品久久久一二三区| 国产精品久久久久久av福利| 色婷婷香蕉在线一区二区| 福利视频在线播放| 欧美人与动zozo在线播放| 色 综合 欧美 亚洲 国产| 国产成人av大片大片在线播放| 国产在线精品视频二区| 亚洲色素色无码专区| 精精国产xxxx视频在线播放| 午夜美女裸体福利视频| 亚洲综合久久一本伊一区| 中文字幕无码av波多野吉衣| 久久人人97超碰国产亚洲人| 大帝a∨无码视频在线播放|