在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Gamma-aminobutyric acid receptor subunit beta-2 (Gabrb2), partial

Recombinant Rat Gamma-aminobutyric acid receptor subunit beta-2 (Gabrb2), partial

  • 中文名稱：
    大鼠Gabrb2重組蛋白
  • 貨號：
    CSB-YP009147RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Gabrb2重組蛋白
  • 貨號：
    CSB-EP009147RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Gabrb2重組蛋白
  • 貨號：
    CSB-EP009147RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Gabrb2重組蛋白
  • 貨號：
    CSB-BP009147RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Gabrb2重組蛋白
  • 貨號：
    CSB-MP009147RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabrb2
  • Uniprot No.：
  • 別名：
    Gabrb2; Gabrb-2; Gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
  • 基因功能參考文獻：
    1. the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions. PMID: 27382064
    2. The data of this study reveal that GABAA receptor beta2 and beta3 decrease following 1 h of acute restraint stress and may play a critical role in stress-induced hyperalgesia. PMID: 24992900
    3. These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops. PMID: 23205938
    4. The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the alpha(1)beta(2)gamma(2)L receptor. PMID: 21474657
    5. Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors. PMID: 20937799
    6. Results indicate that beta2 Loop 9 is involved in receptor activation by GABA, propofol, and pregnanolone and that beta2(Q185) participates in hydrophilic interactions that are important for stabilizing the closed state of the GABA(A) receptor. PMID: 20007704
    7. The magnitude of GABA(A) receptor beta 2 subunit mRNA expression in rat telencephalic neuronal populations is found to be inferior to that of the distantly related hedgehog. PMID: 11845246
    8. TM1 glycine on the beta2 subunit is involved with desensitization of GABA-,pentobarbital-, and propofol-induced currents PMID: 11877425
    9. analysis of the role of a single M1 residue in the beta2 subunit of GABAA receptor alters channel gating of GABAA receptor in anesthetic modulation and direct activation PMID: 12939268
    10. identified a number of highly conserved charged residues in the GABAA-R beta2 subunit that appear to be involved in receptor activation PMID: 14610076
    11. GABA(B2) subunit mRNAs were were first weakly detected on GD 13.5. On GD 15.5, 17.5, and 19.5, these subunit mRNAs were found in the retina, hippocampus, cerebral cortex, spinal cord, and cerebellum area. PMID: 15158077
    12. Slow GABA-A receptor kinetics are not governed by simple ligand-receptor interactions. Access to the steroid direct gating (and perhaps potentiation) site occurs via the plasma membrane & the membrane concentration of steroid governs direct gating. PMID: 15282269
    13. To elucidate the role of the beta2Ile154-Asp163 region in GABA(A)R activation, each residue was individually mutated to cysteine and coexpressed with wild-type alpha1 subunits in Xenopus laevis oocytes. PMID: 15601928
    14. A gate exists between the picrotoxin binding site and the channel's extracellular end, consistent with a closed channel gate in the middle of the channel. PMID: 17227918
    15. Tonic activation of GABA-A receptors in developing hippocampus enhances glutamergic cell excitability and synaptic activity. PMID: 17317750
    16. alpha6-beta2-delta GABA A receptors exist in high/low affinity states and expression of subunits alters equilibrium between the two states. PMID: 17395622
    17. Using wild type/mutated receptor subunits to identify compounds with anesthetic effect. PMID: 18292428
    18. Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. PMID: 18387955
    19. Intriguingly, although there is no direct interaction between GISP and the GABA(B2) subunit, their co-expression in HEK293 cells increases levels of GABA(B2). PMID: 18643869

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB2 sub-subfamily
  • 組織特異性：
    Expressed in brain (at protein level).
  • 數據庫鏈接：


主站蜘蛛池模板： 一本色道久久88加勒比—综合 | 欧美精品黑人粗大破除| 欧美成人www免费全部网站| 亚洲色大成网站www久久九| 久久久久噜噜噜亚洲熟女综合| 午夜成人爽爽爽视频在线观看| 开心色怡人综合网站| 国产一在线精品一区在线观看| 国内精品免费久久久久电影院| 亚洲精品1卡2卡三卡4卡乱码| 乱码精品一区二区三区| 免费拍拍拍网站| 99国产精品白浆在线观看免费| 日本三级香港三级人妇三| 亚洲人成电影综合网站色www| 久久亚洲国产成人精品无码区 | 精品亚洲欧美无人区乱码| 国产成人无码专区| 成人无码潮喷在线观看| 欧美老妇乱辈通奷| 无码专区一va亚洲v专区在线| 成全世界免费高清观看| 双乳被一左一右吃着动态图| 国产精品免费久久久久电影| 国产又黄又爽又猛免费视频播放| 国产在线不卡视频免费视频| 天堂亚洲国产中文在线| 男女裸体影院高潮| 亚欧无线一线二线三线区别| 印度妓女野外xxww| 久久精品国产精品国产精品污| 又黄又爽吃奶视频在线观看 | 精品国产一区二区三区四区在线看| 久久国产精品日本波多野结衣| 一本色道久久99一综合| 99久久国产宗和精品1上映| 中文字幕在线亚洲日韩6页| 五月天精品视频在线观看| 美女张开腿黄网站免费| 天堂а√在线最新版中文| 日韩久久久久久中文人妻|