在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Ephrin type-B receptor 1 (Ephb1), partial

Recombinant Rat Ephrin type-B receptor 1 (Ephb1), partial

  • 中文名稱：
    大鼠Ephb1重組蛋白
  • 貨號：
    CSB-YP007729RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Ephb1重組蛋白
  • 貨號：
    CSB-EP007729RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Ephb1重組蛋白
  • 貨號：
    CSB-EP007729RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Ephb1重組蛋白
  • 貨號：
    CSB-BP007729RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Ephb1重組蛋白
  • 貨號：
    CSB-MP007729RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ephb1
  • Uniprot No.：
  • 別名：
    Ephb1; Elk; Epth2; Ephrin type-B receptor 1; EC 2.7.10.1; ELK; Tyrosine-protein kinase receptor EPH-2
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation.
  • 基因功能參考文獻：
    1. These results indicate that CaMKII and ERK interact to promote activation in hypertrophy; the inhibition of CaMKII-ERK interaction offers a novel therapeutic approach to limit cardiac hypertrophy. PMID: 26110816
    2. MEK/ERK activity controls the levels of MKP-1 and, thereby, regulates JNK activity in polyamine-depleted cells. PMID: 24253595
    3. results suggest that the PGE(2)-EP4-ERK pathway increases the number of osteo-adipogenic bipotential progenitor cells, with a resultant increase in adipogenesis in RC cell cultures. PMID: 22265865
    4. In the pathogenesis of hyperoxia-induced lung fibrosis in neonatal rats, ERK phosphorylation might mediate angiotensin II type 1 receptor activation. PMID: 21791939
    5. identified expression of EphrinB1 in prostatic mesenchyme and suggest that the EphrinB signalling system acts as a regulator of prostate growth. EphrinB-EphB signalling may function as an autocrine regulator of mesenchyme PMID: 20633976
    6. analysis of gamma-secretase cleavage of five substrates, APP, Notch1, N-cadherin, ephrinB and p75 neurotrophin receptor (p75-NTR) in membranes isolated from embryonic, young or old adult rat brains PMID: 20333303
    7. Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B. PMID: 19864302
    8. Stimulation by EphrinB2 modulates the functional consequences of NMDA receptor activation; suggest a mechanism whereby activity-independent and dependent signals converge to regulate the development and remodeling of synaptic connections. PMID: 11799243
    9. Signaling between ephrin-B2 on astrocytes and EphB2 on meningeal fibroblasts results in the development of the glial scar and the exclusion of meningeal fibroblasts from the injured spinal cord. PMID: 12944508
    10. EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion PMID: 16049340
    11. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2. PMID: 16394100
    12. Expression of ephrinB2 is enhanced by nerve injury in neurons in DRG and spinal cord, while its receptor EphB1 is expressed in spinal cord. PMID: 17621205
    13. Furthermore, the neuroprotective effect of luteolin is abolished by the inhibition of the luteolin-induced ERK1/2-activation. Our results highlight the relevance of Nrf2 for neural cell survival conferred by flavones. PMID: 17982879
    14. These findings indicate that ephrinB-EphB receptor activation and redistribution in DRG and DH neurons after nerve injury could contribute to neuropathic pain. This study may also provide a new mechanism underlying DR-induced analgesia in clinic. PMID: 18321739
    15. Long-term potentiation of synapses between neurons of the dorsal root ganglion and the spinal dorsal horn requires ephrinB1-EphB receptor signaling. PMID: 18448254
    16. Our results demonstrated for the first time that ERK and JNK were activated in rat optic nerves during early and later periods of reperfusion, suggesting their potential active role in the response of cerebral white matter tissue to ischemic injury. PMID: 19011585

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性：
    Restricted to brain and testes.
  • 數據庫鏈接：


主站蜘蛛池模板： 韩国理伦片一区二区三区在线播放| а天堂中文最新版在线| 亚洲一区二区三区四区五区六区| 亚洲 自拍 另类 欧美 综合| 国产蝌蚪视频一区二区三区| 亚洲精品无码成人片久久| 亚洲自偷自拍另类11p| 国产欧美一区二区三区在线看| 婷婷色中文字幕综合在线| 国产99视频精品免费视频76| 成人午夜亚洲精品无码区| 国产精品三级在线观看无码| 四虎成人精品无码永久在线| 国产av影片麻豆精品传媒| 成人国内精品久久久久一区| 国产成人亚洲综合无码精品| 国产精品一区二区香蕉| 成人无码精品免费视频在线观看| 扒开双腿疯狂进出爽爽爽视频| 波多野结衣一区二区三区高清 | 国内熟妇人妻色在线视频| 东京热人妻丝袜无码av一二三区观 | 韩国精品福利一区二区三区| 久久综合色一综合色88| 国产午夜草莓视频在线观看 | 国产免费无码一区二区三区| 精品国产精品久久一区免费式| 亚洲视频无码高清在线| 亚洲aⅴ无码专区在线观看q| 97se亚洲精品一区| 中文国产乱码在线人妻一区二区| 13小箩利洗澡无码视频网站| 免费看又黄又无码的网站| 无码日本精品xxxxxxxxx| 久久精品国产99久久久小说| 人人妻人人澡人人爽精品日本| 三男一女吃奶添下面视频| 国产毛片不卡野外视频| 亚洲国产精品隔壁老王| 欧洲亚洲色一区二区色99 | 在线精品亚洲一区二区|