在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Egl nine homolog 1 (Egln1)

  • 中文名稱:
    大鼠Egln1重組蛋白
  • 貨號:
    CSB-YP007481RA
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Egln1重組蛋白
  • 貨號:
    CSB-EP007481RA
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Egln1重組蛋白
  • 貨號:
    CSB-EP007481RA-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Egln1重組蛋白
  • 貨號:
    CSB-BP007481RA
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Egln1重組蛋白
  • 貨號:
    CSB-MP007481RA
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Egln1Egl nine homolog 1; EC 1.14.11.29; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; Fragment
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full length protein
  • 表達區(qū)域:
    1-222
  • 氨基酸序列
    MNKHGICVVD DFLGRETGQQ IGDEVRALHD TGKFTDGQLV SQKSDSSKDI RGDKITWIEG KEPGCETIGL LMSSMDDLIR HCSGKLGNYR INGRTKAMVA CYPGNGTGYV RHVDNPNGDG RCVTCIYYLN KDWDAKVSGG ILRIFPEGKA QFADIEPKFD RLLFFWSDRR NPHEVQPAYA TRYAITVWYF DADERARAKV KYLTGEKGVR VELKPNSVSK DV
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN1 is the most important isozyme under normoxia and, through regulating the stability of HIF1, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality. Target proteins are preferentially recognized via a LXXLAP motif.
  • 基因功能參考文獻:
    1. PHD2 controls TNF-alpha effects by positively regulating NF-kappaB signaling, whereas NF-kappaB mediates cytokine-dependent PHD2 expression. PMID: 25635047
    2. PHD-2 KO mice showed significantly accelerated wound closure relative to WT. PMID: 24695462
    3. Impaired PHD2 response to high salt intake in the renal medulla may represent a novel mechanism for hypertension in Dahl S rats, and inhibition of PHD2 in the renal medulla could be a therapeutic approach for salt-sensitive hypertension. PMID: 24190904
    4. Renal medullary PHD2 is an important regulator in renal adaptation to high salt intake. PMID: 22686466
    5. PHD2 may directly interact with PDE4D to function as a novel regulator of the intracellular cAMP levels in cardiomyocytes. PMID: 22975349
    6. Data show that knockdown of PHD2, a major isoform of PHDs, by RNA interference reduced AT(1)R expression. PMID: 21825224
    7. High-salt intake inhibits PHD2 in the renal medulla, thereby upregulating the HIF-1alpha expression in rat renal medulla. PMID: 20308610
    8. identified the three forms of prolyl hydroxylase in rats and demonstrated that PHD2 has a role in proline hydroxylation, which regulates hypoxic preconditioning PMID: 12876291
    9. Decrease in PHD2 expression level is associated with ischemia. PMID: 19349364

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Expressed in heart, liver, kidney, brain, liver and testis. Highest levels in heart, lowest in liver.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产品无码一区二区三区在线| 亚洲自偷自偷偷色无码中文 | 尤物yw午夜国产精品大臿蕉| 女被啪到深处喷水gif动态图| 免费午夜福利不卡片在线播放| 亚洲综合天堂av网站在线观看| 香蕉久久一区二区三区啪啪| 久久中文字幕无码a片不卡古代| 亚洲中文精品久久久久久| 亚洲精品久久久狠狠爱小说| 麻豆一区二区99久久久久| 国产乱子伦一区二区三区| 中文字幕三级人妻无码视频| 狂野欧美激情性xxxx在线观看| 久久av无码精品人妻系列试探| 热re99久久精品国99热| 日韩精品av一区二区三区| 国产丝袜肉丝视频在线| 欧美精品一国产成人综合久久| 玩弄中年熟妇正在播放| 免费无码一区二区三区蜜桃大| 体验区试看120秒啪啪免费 | 又爽又黄又无遮挡的激情视频| 综合亚洲伊人午夜网| 妺妺窝人体色www在线小说| 精品成人免费国产片| 亚洲成_人网站图片| 狠狠色综合激情丁香五月| 男人的好看免费观看在线视频| 色伦专区97中文字幕| 亚洲精品久久久久久中文传媒| 7777久久亚洲中文字幕| 日韩综合亚洲色在线影院| 亚洲午夜福利精品无码不卡| 天堂8在线新版官网| 亚欧欧美人成视频在线| 人妻aⅴ中文字幕无码| 四虎国产精品免费久久久| 男女裸体下面进入的免费视频| 日本免费一本一二区三区| 亚洲码欧美码一区二区三区|