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  4. Recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Enpp2), partial

Recombinant Rat Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Enpp2), partial

  • 中文名稱：
    大鼠Enpp2重組蛋白
  • 貨號：
    CSB-YP737374RA
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Enpp2重組蛋白
  • 貨號：
    CSB-EP737374RA
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Enpp2重組蛋白
  • 貨號：
    CSB-EP737374RA-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Enpp2重組蛋白
  • 貨號：
    CSB-BP737374RA
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Enpp2重組蛋白
  • 貨號：
    CSB-MP737374RA
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Enpp2
  • Uniprot No.：
  • 別名：
    Enpp2; Atx; Npps2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; EC 3.1.4.39; Autotaxin; Extracellular lysophospholipase D; LysoPLD
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
  • 基因功能參考文獻：
    1. ENPP2 protects cardiomyocytes from ferroptosis. PMID: 29551679
    2. The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed. PMID: 28539367
    3. This study demonstrated that reduction of the Enpp2 mRNA expression in hippocampus of thyroidectomized Wistar rats. PMID: 26861177
    4. Data show that bile salts bind autotaxin (ATX) and inhibit lysophosphatidic acid (LPA) production. PMID: 27075612
    5. These findings identify ATX and LPA2 as radiation-regulated genes that appear to play a physiological role in DNA repair. PMID: 26027517
    6. This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modulator of oligodendrocyte differentiation PMID: 26269646
    7. Our findings suggest that ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy. PMID: 22864860
    8. A physical interaction between autotaxin (ATX) and P2Y12 receptor provides the basis for an ATX-MORFO-P2Y12 signaling axis crucial for cellular function. PMID: 22139091
    9. Exocrine pancreatic carcinogenesis shows autotaxin expression PMID: 22952646
    10. These results suggest that uterine Enpp2 may be regulated by estrogens and plays a role in reproductive functions during female rat development. PMID: 22122904
    11. The aim of this study was to explain whether serum autotaxin (ATX) activity might be a target for regulation of liver fibrosis. PMID: 20957682
    12. Identified is a hydrophobic lipid-binding pocket in autotaxin and mapped are key residues for catalysis and selection between nucleotide and phospholipid substrates. PMID: 21240271
    13. crystals of autotaxin diffracted to a maximum resolution of 2.05 A and belonged to space group P1, with unit-cell parameters a=53.8, b=63.3, c=70.5 A, alpha=98.8, beta=106.2, gamma=99.8 degrees PMID: 20823544
    14. allowed the formation of micrometre-thick crystals of ENPP2 that were suitable for collecting diffraction data to 2.6 A degrees resolution PMID: 20823545
    15. Autotaxin has lysophospholipase D activity. It suggests that autocrine or paracrine production of LPA contributes to tumor cell motility, survival, and proliferation PMID: 12119361
    16. release of PD-Ialpha/ATX may be critically involved in the regulation of the initial stages of myelination, i.e., oligodendrocyte remodeling, via modulation of oligodendrocyte-extracellular matrix interactions in a matricellular fashion. PMID: 12837632
    17. the N-terminal hydrophobic sequence of autotaxin functions as a signal peptide, not as a transmembrane segment, and thus autotaxin is synthesized as a secreted protein PMID: 16436050
    18. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin. PMID: 16837466
    19. The purified enzyme hydrolyzed saturated forms of LPC more robustly than unsaturated forms. PMID: 17071136
    20. Following neurotrauma, autotaxin is strongly up-regulated in reactive astrocytes adjacent to the lesion. PMID: 17192809
    21. defines an essential role for the Asn-524-linked glycan chain of ectonucleotide pyrophosphatase/phosphodiesterase 2 PMID: 17307740
    22. PD-Ialpha/ATX promotes oligodendroglial process network formation and expansion via the cooperative action of multiple functional sites located within the MORFO domain. PMID: 18164210
    23. Both NPP2 isoforms have shown a similar pattern of expression among all structures. PMID: 18565716
    24. These data show that the nuclease-like domain is crucial for catalysis by NPP2 and is a possible target to generate inhibitors. PMID: 19329427

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Nucleotide pyrophosphatase/phosphodiesterase family
  • 組織特異性：
    Abundantly expressed in cerebrum and cerebellum. Localized in secretory epithelial cells in the brain and the eye including choroid plexus epithelial cells, ciliary epithelial cells, iris pigment epithelial cells, and retinal pigment cells.
  • 數(shù)據(jù)庫鏈接：

    KEGG: rno:84050

    UniGene: Rn.20403



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