在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat E3 ubiquitin-protein ligase RNF168 (Rnf168)

Recombinant Rat E3 ubiquitin-protein ligase RNF168 (Rnf168)

  • 中文名稱：
    大鼠Rnf168重組蛋白
  • 貨號：
    CSB-YP019854RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Rnf168重組蛋白
  • 貨號：
    CSB-EP019854RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Rnf168重組蛋白
  • 貨號：
    CSB-EP019854RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Rnf168重組蛋白
  • 貨號：
    CSB-BP019854RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Rnf168重組蛋白
  • 貨號：
    CSB-MP019854RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Rnf168
  • Uniprot No.：
  • 別名：
    Rnf168; E3 ubiquitin-protein ligase RNF168; EC 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-564
  • 氨基酸序列
    MAAPKNSIPS LAECQCGICM EILVEPVTLP CNHTLCNPCF QSTVEKANLC CPFCRRRVSS WTRYHTRRNS LVNTDLWEII QKHYAKECKL RISGQESKEI VDEYQPVRLL SKPGELRREY EEEISKVEAE RQASKEEENK ASEEYIQRLL AEEEEEEKRR TERRRSEMEE QLRGDEELAR RLSTSINSNY ERNILASPLS SRKSDPVTNK SQKKNTNKQK NFGDIQRYLS PKSKPGTAWA CKTEHGEDMC KSKETDSSDT KSPVLQDTDV EESMPTHSPQ TCPETQGQGP EPLTEMPVPW LCARNAEQCL EGKAEAVSTN PDDSCIVNDG GPRAIVSNSK EAAVKPPTKI ENEEYSVSGV TQLTGGNGVP TESRVYDLLV GKEISERENQ ESVFEEVMDP CFSAKRRKIF ITSSLDQEET EVNFTQKLID LEHMLFERHK QEEQDRLLAL QLQKEADKEK MVPNRQKGSP DQYQLRTSSP PDGLLNGQRK NVKDRNSPKQ TADRSKSQRS RKGEYWETFE STWKGSVNGT KMPTPRKDSC NVSKRACPLQ HRSAQKSILQ MFQR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RNF168 family
  • 數據庫鏈接：


主站蜘蛛池模板： а天堂中文官网| 午夜伦费影视在线观看| 女人夜夜春精品a片| www国产精品内射老师| 久久久精品区二区三区免费| 亚洲精品综合在线影院| 在线看免费无码av天堂的| 国产精品丝袜黑色高跟鞋| 隔壁老王国产在线精品| 女人和拘做受全程看视频| 成人无码视频免费播放| 丰满人妻av无码一区二区三区| 亚洲中文字幕无码日韩| 国产在线乱码一区二区三区| 中文字幕乱码熟妇五十中出色欲| 天天躁日日躁狠狠躁av麻豆男男 | 国产亚洲精品在av| 欧美人妻aⅴ中文字幕| 精品久久久久久亚洲精品 | 久久99精品久久久久久蜜芽| 亚洲国产精品久久久久久无码| 级毛片内射视频| av中文无码乱人伦在线观看| 欧美35页视频在线观看| 一边摸一边抽搐一进一出视频| 狠狠五月深爱婷婷网| 欧美最猛性xxxxx大叫| 337p日本欧洲亚洲大胆精品 | 国产熟妇勾子乱视频| 中文字幕av一区乱码| 国产青榴视频在线观看| 国产最新进精品视频| 日韩精品无码一区二区三区视频| 久久天天躁狠狠躁夜夜96流白浆 | 天堂aⅴ无码一区二区三区| 未满十八18禁止午夜免费网站| 99精品众筹模特自拍视频| 午夜理论片yy8860y影院| 久久亚洲中文无码咪咪爱| 国偷自产视频一区二区久 | 夜精品一区二区无码a片 |