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  4. Recombinant Rat D site-binding protein (Dbp)

Recombinant Rat D site-binding protein (Dbp)

  • 中文名稱：
    Recombinant Rat D site-binding protein(Dbp)
  • 貨號：
    CSB-YP006528RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat D site-binding protein(Dbp)
  • 貨號：
    CSB-EP006528RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat D site-binding protein(Dbp)
  • 貨號：
    CSB-EP006528RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat D site-binding protein(Dbp)
  • 貨號：
    CSB-BP006528RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat D site-binding protein(Dbp)
  • 貨號：
    CSB-MP006528RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DbpD site-binding protein; Albumin D box-binding protein; Albumin D-element-binding protein; D site albumin promoter-binding protein 1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-325
  • 氨基酸序列
    MARPLSDRTP GPLLLGGPAG APPGGGALLG LRSLLQGNSK PKEPASCLLK EKERKATLPS APVPGPVLET AGPADAPTGA VSGGGSPRGR SGPVAGPSLF APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGLSP APSPARTPAP SPGPGSCSSS SPRSSPGHAP ARATLGAAGG HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKVQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE VVAVRQELSH YRAVLSRYQA QHGTL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
  • 基因功能參考文獻：
    1. Data show that the expression of clock genes Per2, Bmal1 and Dbp follow a diurnal rhythm in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleu but the phase and amplitude of the rhythms of each gene vary across the 3 regions. PMID: 25068868
    2. The localization and diurnal variation of BMAL1, DBP and PER2 are changed in remnant kidney of 5/6 nephrectomy rats and are involved in diurnal rhythm of renal function. PMID: 23738784
    3. Data show that knockdown of DBP, D-box positive regulator, led to a short-period phenotype, and overexpression of DBP produced a long-period rhythm, while knockdown and overexpression of E4BP4, D-box negative regulator, had the opposite effect of DBP. PMID: 21635892
    4. Dbp and estrogen regulate the expression of Kiss1 in the anteroventral periventricular nucleus PMID: 21458520
    5. natural body temperature rhythms can affect circadian gene expression PMID: 12372249
    6. per2 and dbp expression in the heart and liver is increased in streptozotocin-induced diabetes PMID: 15792371
    7. Data suggest that DBP may represent an important transcriptional link between glucagon-like peptide-1 receptor activation and neuroplasticity in the hippocampus. PMID: 16257226
    8. DBP has the ability to bind the DBP binding site located in the distal promoter region of the PEPT1 gene & induce the transcriptional activity. These findings indicate that DBP plays pivotal roles in the circadiran oscillation of PEPT1. PMID: 18583459
    9. The rhythmic mRNA expression of clock genes (Clock, Bmal1, Cry1, and Dbp) is not attenuated in the liver and visceral adipose tissues of Goto-Kakizaki rats, a model of nonobese, type 2 diabetes, as compared to control Wistar rats. PMID: 19387896

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, PAR subfamily
  • 組織特異性：
    Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.
  • 數據庫鏈接：


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