在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Copper-transporting ATPase 1 (Atp7a), partial

Recombinant Rat Copper-transporting ATPase 1 (Atp7a), partial

  • 中文名稱：
    Recombinant Rat Copper-transporting ATPase 1(Atp7a) ,partial
  • 貨號：
    CSB-YP002414RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Copper-transporting ATPase 1(Atp7a) ,partial
  • 貨號：
    CSB-EP002414RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Copper-transporting ATPase 1(Atp7a) ,partial
  • 貨號：
    CSB-EP002414RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Copper-transporting ATPase 1(Atp7a) ,partial
  • 貨號：
    CSB-BP002414RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Copper-transporting ATPase 1(Atp7a) ,partial
  • 貨號：
    CSB-MP002414RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Atp7a
  • Uniprot No.：
  • 別名：
    Atp7a; MnkCopper-transporting ATPase 1; EC 7.2.2.8; Copper pump 1; Menkes disease-associated protein homolog
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis. Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway. Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions. May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3. In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. CTR1 and ATP7A play important roles in Cu transport in choroidal epithelial cells, and the Pb-induced intracellular Cu accumulation appears to be mediated, at least in part, via the alteration of CTR1 and ATP7A expression levels following Pb exposure. PMID: 24316150
    2. Atp7a knockdown in IEC-6 cells enhanced transepithelial iron flux via a novel molecular mechanism involving transcriptional induction of Fpn1 gene expression. PMID: 24174620
    3. Iron chelation with copper loading increased Atp7a mRNA and protein levels. PMID: 23174565
    4. Multiple Atp7a transcript and protein variants exist in rodent intestinal epithelial cells and are induced by dietary iron deprivation. PMID: 22579041
    5. these results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier PMID: 22442359
    6. Data show that the Atp7a gene is upregulated by direct interaction with HIF2alpha, demonstrating coordinate regulation with genes related to intestinal iron homeostasis. PMID: 21346155
    7. Conclude that novel Atp7a protein variants may exist in rat intestinal epithelial cells, with different intracellular locations and potentially distinct physiological functions. PMID: 19679821
    8. Atp7a plays an important role in copper-dependent vascular smooth muscle cell migration and may contribute to neointimal formation after experimental vascular injury. PMID: 20671235
    9. ATP7A is involved in copper loading observed during iron deficiency and increased intestinal copper transport is of physiological relevance PMID: 16081413
    10. Immunolocalization of MNK was demonstrated mainly over the trans Golgi network of parotid acinar cells; immature and mature secretory granules were also labelled. PMID: 16185750
    11. Prolactin stimulated Cu transport as a result of increased Ctr1 and Atp7A abundance at the plasma membrane in mammary gland PMID: 16741141
    12. Intestinal cells contain dispersed vesicular compartment that actively sequesters excess cytoplasmic copper. PMID: 17158254

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
  • 組織特異性：
    Expressed in hippocampal neuron (at protein level). Expressed in anterior pituitary gland (at protein level).
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲欧美日韩精品久久亚洲区| 欧美 亚洲 日韩 中文2019| 久久久亚洲精品一区二区三区| 97精品人人a片免费看| 国产精品乱码人妻一区二区三区| 久久无码无码久久综合综合| 日本无卡码高清免费v| 亚洲日本精品国产一区vr| 老司机午夜福利av无码特黄a| 中文字幕日产无码| 亚洲综合精品伊人久久| 中文有码人妻字幕在线| 奇米777四色影视在线看| 欧美 日韩 人妻 高清 中文| 成人国产网站v片免费观看| 亚洲精品无码mv在线观看网站| 久久久久成人片免费观看蜜芽| 亚洲精品成人无码中文毛片不卡 | www亚洲精品少妇裸乳一区二区| 亚洲情xo亚洲色xo无码| 四川骚妇无套内射舔了更爽 | 法国伦理少妇愉情| 成人欧美日韩一区二区三区| 成人欧美一区二区三区a片| 免费无码专区在线视频| 亚洲精品国产suv一区88| 女人被黑人躁得好爽视频| 亚洲国产一区二区精品无码| 大胸美女被吃奶爽死视频| 欧洲熟妇性色黄| 久久精品国产999久久久| 人妻精品人妻无码一区二区三区| 欧美一区二区三区成人久久片| 国内精品久久久久久久久电影网 | 特黄做受又粗又长又大又硬| 欧美 日韩 国产 另类 图片区| 又色又爽又黄的视频软件app| 性色a∨精品高清在线观看| 日韩欧美亚洲中文乱码| 成人免费无码大片a毛片| 国产精品不卡无码av在线播放 |