在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Chymase (Cma1)

Recombinant Rat Chymase (Cma1)

  • 中文名稱：
    Recombinant Rat Chymase(Cma1)
  • 貨號：
    CSB-YP005599RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Chymase(Cma1)
  • 貨號：
    CSB-EP005599RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Chymase(Cma1)
  • 貨號：
    CSB-EP005599RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Chymase(Cma1)
  • 貨號：
    CSB-BP005599RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Chymase(Cma1)
  • 貨號：
    CSB-MP005599RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cma1; Mcpt3Chymase; EC 3.4.21.39; Alpha-chymase; Mast cell protease 3; rMCP-3; Mast cell protease 5; rMCP-5; Mast cell protease III; rMCP-III
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    22-247
  • 氨基酸序列
    IIGGTECIP HSRPYMAYLE IVTSDNYLSA CSGFLIRRNF VLTAAHCAGR SITVLLGAHN KTYKEDTWQK LEVEKQFIHP NYDKRLVLHD IMLLKLKEKA KLTLGVGTLP LSANFNFIPP GRMCRAVGWG RTNVNEPASD TLQEVKMRLQ EPQSCKHFTS FQHKSQLCVG NPKKMQNVYK GDSGGPLLCA GIAQGIASYV HPNAKPPAVF TRISHYRPWI NKILREN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
  • 基因功能參考文獻：
    1. The pathobiologic response in WKY rats was directly linked to increases in cardiac gene expression and enzymatic activity of chymase and modest reductions in ACE2 activity. PMID: 28748720
    2. Compared to chymase, ACE-mediated angiotensin-(1-12) metabolism in the heart was several fold lower. Overall our findings suggest that angiotensin-(1-12), not Ang I, is the better substrate for Ang II formation by chymase in adult rats. PMID: 27465904
    3. In a pure VO model, chymase produced in adult cardiac fibroblasts leads to autophagic degradation of newly synthesized intracellular procollagen I, suggesting a new role of chymase in extracellular matrix degradation. PMID: 26807691
    4. The results indicate an important role for chymase in inducing fibrosis through TGF-beta1 activation, parallel with Ang II effects. PMID: 22875344
    5. Chymase-secreting mast cells mediate apoptosis of neighboring smooth muscle cells through a mechanism involving degradation of pericellular fibronectin and disruption of the p-focal adhesion kinase-dependent cell-survival signaling cascade. PMID: 12588765
    6. rat alpha-chymase has converted to elastase-like substrate specificity, perhaps associated with an adoption of new biological targets PMID: 12900423
    7. Based on the results, this study suggested rMCP-5 is a key promoter of angiogenesis in the rat. PMID: 15723097
    8. Plasma ANG II does not appear to regulate intrarenal chymase activity. ACE-independent ANG II production by chymase may provide mechanism for augmenting intrarenal ANG II in ischemic kidney in renovascular hypertension. PMID: 15869764
    9. By disrupting the NF-kappaB-mediated survival-signaling pathway, activated chymase-secreting mast cells can mediate apoptosis of cultured arterial SMCs. PMID: 16460729
    10. Angiotensin II-forming chymase may play a role in the proliferation of the medial layer in the lung arterioles of monocrotaline-induced pulmonary hypertensive rats. PMID: 16690960
    11. These results suggest that chymase can promote cardiac fibroblast proliferation and collagen synthesis via TGF-beta 1/Smad pathway rather than angiotensin II, which is implicated in the process of myocardial fibrosis. PMID: 18057996
    12. chymase inactivates the FAK-mediated cell survival signaling PMID: 18079408

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Cytoplasmic granule. Note=Secretory granules.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 組織特異性：
    Mast cells.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 日韩va中文字幕无码电影 | 亚洲国产成人精品无码区一本| 亚洲人成电影在线播放| 国内精品免费网站牛牛| 高清不卡一区二区三区| 在线看片免费人成视频影院看| 美女视频黄是免费| 日本乱理伦片在线观看中文| 久久国产色av免费看| 欧美特大特白屁股ass| 国产一区二区精品久久| 国产亚洲日韩av在线播放不卡 | 日本人妻中文字幕乱码系列| 中文字幕乱码熟女人妻水蜜桃| 国产亚洲精品久久久性色情软件| 国产鲁鲁视频在线观看| 亚洲gv永久无码天堂网| 五月av综合av国产av| 免费夜色污私人影院在线观看| 色婷婷亚洲精品综合影院| 亚洲精品一区久久久久一品av | 成人国产精品一区二区网站公司| 欧美阿v高清资源在线| 国产精品无码专区久久久| 少妇无码一区二区三区免费| 国产96色在线 | 国| 男女啪啪永久免费观看网站| 亚洲日本乱码一区二区产线一∨ | 五月av综合av国产av| 在线天堂资源www中文| 四虎影视88aa久久人妻| 五月婷婷开心中文字幕| 一本无码人妻在中文字幕| 亚洲精品日本一区二区三区 | 亚洲欧美日韩成人综合一区| 中文字幕无码免费久久99| 100禁毛片免费40分钟视频| 性大毛片视频| 人人摸人人搞人人透| 伊人久久大香线蕉综合5g| 欧美激情一区二区三区|