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  4. Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial (Cyp11a1)

Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial (Cyp11a1)

  • 中文名稱：
    Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial(Cyp11a1)
  • 貨號：
    CSB-YP006389RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial(Cyp11a1)
  • 貨號：
    CSB-EP006389RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial(Cyp11a1)
  • 貨號：
    CSB-EP006389RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial(Cyp11a1)
  • 貨號：
    CSB-BP006389RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Cholesterol side-chain cleavage enzyme, mitochondrial(Cyp11a1)
  • 貨號：
    CSB-MP006389RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cyp11a1; Cyp11a; Cyp11a-1Cholesterol side-chain cleavage enzyme; mitochondrial; EC 1.14.15.6; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    37-526aa
  • 氨基酸序列
    ISSTNSPRSFNEIPSPGDNGWINLYHFLRENGTHRIHYHHMQNFQKYGPIYREKLGNMES VYILDPKDAATLFSCEGPNPERYLVPPWVAYHQYYQRPIGVLFKSSDAWRKDRIVLNQEV MAPDSIKNFVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGER LGMLEEIVDPESQRFIDAVYQMFHTSVPMLNMPPDLFRLFRTKTWKDHAAAWDVIFSKAD EYTQNFYWDLRQKRDFSKYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWNL YEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIV NDLVLRNYKIPAKTLVQVASYAMGRESSFFPNPNKFDPTRWLEKSQNTTHFRYLGFGWGV RQCLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNFQPLKQDLG STMPRKGDTV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
  • 基因功能參考文獻：
    1. epigenetic changes such as histone modifications and chromatin remodeling occurred in the promoter region in granulosa cellss undergoing luteinization during ovulation PMID: 27428926
    2. These results suggest that P450scc overexpression and the resultant increase of 3alpha,5alpha-THP-positive cells in the ventral tegmental area reduces ethanol reinforcement. PMID: 24760842
    3. Data from a rat model of polycystic ovary syndrome suggest that hyperandrogenism develops and this may partially up-regulate expression of steroidogenic enzymes (P450scc and CYP17 [cytochrome P450 family 17]) in ovarian tissue. PMID: 22798247
    4. Data suggest that variations in intake of sodium and potassium act on expression of P450scc in adrenal zona glomerulosa. PMID: 22217827
    5. Testosterone has a direct stimulatory effect on Cyp19 and P450scc expression in ovarian granulosa cells PMID: 21273442
    6. Results describe the expression and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1), which converts cholesterol into pregnenolone, in adult rat kidney. PMID: 21075169
    7. Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element. PMID: 12145340
    8. the presence and activity of cytochrome P450scc in pain pathways were studied; P450scc-immunoreactive cells were localized in dorsal root ganglia, spinal cord dorsal horn, nociceptive supraspinal nuclei and somatosensory cortex PMID: 12911631
    9. members of the Sp transcription family play a role in activating cholesterol desmolase gene transcription in the nervous system, and Ku antigen may further augment this activation PMID: 14576192
    10. Expression of P450scc was studied in the rat kidney from birth to adulthood. PMID: 15026086
    11. purified P450scc in a reconstituted system or P450scc in adrenal mitochondria can add one hydroxyl group to vitamin D3 with subsequent hydroxylation being observed for reconstituted enzyme but not for adrenal mitochondria PMID: 16098191
    12. CYP expression and induction profiles and the morphological features of WIF-B9 cells allow prediction in vitro of the induction and hepatotoxicity profiles of chemical entities. PMID: 16354159
    13. results revealed a decreased expression of mRNA of P450scc enzyme during nephrosis PMID: 16574160
    14. Results showed that more prolonged Status epilepticus was associated with greater P450scc expression. PMID: 16780839
    15. These results suggested that vitamin K is involved in steroid production in the testis through the regulation of Cyp11a. PMID: 16844298
    16. Expression of insl3 and cyp11a were cumulatively decreased by dibutyl phthalate and diethylhexyl phthalate. PMID: 17400582
    17. The decline in progesterone formation following exposure to HPTE in cultured ovarian cells is associated with the inhibition of catalytic activity of P450scc at least in theca-interstitial cells. PMID: 18065196
    18. These results provide evidence for Schwann cells as a major producer of steroid hormones and pregnenolone production by P450scc as an important regulatory step during myelination. PMID: 18373277
    19. Results identify the pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. PMID: 18410379
    20. ERalpha interaction with transcription coregulators, histone acetylases (CBP/SRC-1), and PGC-1alpha is crucial to FSH and TGFbeta1-up-regulated expression of Hsd3b and Cyp11a1, and, thus, progesterone production in rat ovarian granulosa cells. PMID: 18511507

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  • 亞細胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 組織特異性：
    Expressed in the kidney where it localizes to the distal convoluted tubule and the thick ascending limb of the loop of Henle (at protein level). In the ovary, highly expressed in interstitial cells (at protein level). Also expressed in adrenal gland and t
  • 數據庫鏈接：

    KEGG: rno:29680

    STRING: 10116.ENSRNOP00000010831

    UniGene: Rn.1401



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