在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta (Camk2b)

Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta (Camk2b)

  • 中文名稱：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號：
    CSB-YP004466RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號：
    CSB-EP004466RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號：
    CSB-EP004466RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號：
    CSB-BP004466RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Calcium/calmodulin-dependent protein kinase type II subunit beta(Camk2b)
  • 貨號：
    CSB-MP004466RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Camk2b; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; EC 2.7.11.17
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-542
  • 氨基酸序列
    MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD GVKPQTNSTK NSSAITSPKG SLPPAALEPQ TTVIHNPVDG IKESSDSTNT TIEDEDAKAR KQEIIKTTEQ LIEAVNNGDF EAYAKICDPG LTSFEPEALG NLVEGMDFHR FYFENLLAKN SKPIHTTILN PHVHVIGEDA ACIAYIRLTQ YIDGQGRPRT SQSEETRVWH RPDGKWQNVH FHCSGAPVAP LQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
  • 基因功能參考文獻：
    1. VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation. PMID: 25644714
    2. Results suggest that a sodium-dependent glutamate transporter-CaMKIIbeta-actin cytoskeleton axis plays an important role in the regulation of oligodendrocyte maturation and central nervous system myelination PMID: 24866099
    3. BDNF-induced CaMKIIbeta phosphorylation and premature synapse formation were suppressed in GIT1 (S419A) transfected cortical neurons PMID: 23352984
    4. These results identify betaCaMKII as a powerful regulator of lateral habenula neuron function and a key molecular determinant of depression. PMID: 23990563
    5. Study shows targeting of Arc to inactive synapses via a high-affinity interaction with CaMKIIbeta that is not bound to calmodulin. PMID: 22579289
    6. Activation of intracellular CaMKII signaling in the pedunculopontine tegmental nucleus promotes wakefulness and suppresses sleep. PMID: 22114270
    7. The beta isoenzyme of Ca(2+)/calmodulin-dependent kinase type II as possible mediator of somatostatin functions in pituitary tumour cells PMID: 21952434
    8. play distinct role during the development of the retina. PMID: 12234658
    9. Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. PMID: 12873385
    10. Activities of both enzymes increased upon their association, and iPLA(2)beta reaction products reduced CaMKIIbeta activity PMID: 15576376
    11. CaMKIIbeta binding to NR2B C-tail was examined. Translocation was observed for CAMKIIbeta. Ionomycin dispersed CaMKIIbeta into a punctate pattern. PMID: 16436603
    12. F-actin-targeted CaMKIIbeta, but not alpha, was able to phosphorylate actin in vitro even by nonstimulated basal activity. PMID: 16928958
    13. Study suggest that Camk2a is not involved in regulating the acute ethanol sensitivity of NMDA receptors. PMID: 18562151
    14. endogenous CaMKIIbeta, but not CaMKIIalpha, localized to prominent F-actin-rich structures at the soma in embryonic cortical neurons. PMID: 18840684
    15. CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. PMID: 19047462

    顯示更多

    收起更多

  • 亞細胞定位：
    Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the cortical actin cytoskeleton by binding to F-actin in hippocampal cells.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
  • 數據庫鏈接：

    KEGG: rno:24245

    UniGene: Rn.9743



主站蜘蛛池模板： 精品国产一区二区三区四区阿崩| 2018天天拍拍天天爽视频| 国产偷窥熟妇高潮呻吟| 国产成a人片在线观看视频下载| 久久超碰精品一夜七次郎| 亚洲爆乳成av人在线蜜芽| 国产精品女丝袜白丝袜| 国产精品亚洲а∨天堂2021| 正在播放重口老熟女露脸| 亚洲国产精品成人综合色| 亚洲中文字幕无码久久2018| 97精品人妻系列无码人妻| 精品久久久久久无码人妻蜜桃| 国产交换配乱婬视频偷网站| 国产情侣一区二区| 久碰久摸久看视频在线观看| 免费看成人aa片无码视频| 亚洲va中文字幕无码久久不卡| 岛国av动作片在线观看| av午夜久久蜜桃传媒软件| 亚洲综合色婷婷六月丁香宅男大增 | 欧美黑吊大战白妞| 强睡邻居人妻中文字幕| 丝袜无码专区人妻视频| 制服丝袜亚洲中文欧美在线| 国产亚洲产品影市在线产品| 消息称老熟妇乱视频一区二区| 亚洲国产成人精品无码区在线软件| 欧美两根一起进3p在线观看 | 久久国产av影片| 粗大猛烈进出高潮视频免费看 | 国产亚洲精品a片久久久| 97碰碰碰人妻无码视频| 在线看片无码永久av| 亚洲成在人网站无码天堂| 中文字幕人妻互换av久久| 亚洲人成精品久久久久| 久热这里只有精品99| 欧美熟妇性xxx交潮喷| 伊人久久大香线蕉av一区| 亚洲精品久久久久久久久久久捆绑|