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  4. Recombinant Rat Bile salt export pump (Abcb11), partial

Recombinant Rat Bile salt export pump (Abcb11), partial

  • 中文名稱：
    Recombinant Rat Bile salt export pump(Abcb11) ,partial
  • 貨號：
    CSB-YP001049RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Bile salt export pump(Abcb11) ,partial
  • 貨號：
    CSB-EP001049RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Bile salt export pump(Abcb11) ,partial
  • 貨號：
    CSB-EP001049RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Bile salt export pump(Abcb11) ,partial
  • 貨號：
    CSB-BP001049RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Bile salt export pump(Abcb11) ,partial
  • 貨號：
    CSB-MP001049RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Abcb11; Bsep; SpgpBile salt export pump; EC 7.6.2.-; ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion.
  • 基因功能參考文獻：
    1. bile acid homeostasis in rats was regulated through bile acid synthesis and transport in response to Bsep deficiency and roglitazone inhibition PMID: 28645914
    2. Ginsenoside promotion of hepatic cholesterol metabolism does not involve effects on BSEP. PMID: 23108811
    3. FXR regulates BSEP in an isoform-dependent and species-specific manner PMID: 24002920
    4. show that AP2 interacts with BSEP at the canalicular membrane through a tyrosine motif at the carboxyl terminus of BSEP PMID: 22262466
    5. Pericanalicular calcium signaling mediated by InsP3R2 plays an important role in maintaining bile salt secretion through posttranslational regulation of bile salt export pump. PMID: 21748767
    6. The inhibition of BSEP/Bsep resulted in significantly higher intracellular TC(conc) in humans than in rats. PMID: 20147439
    7. The Bsep gene has a suppressive element between nucleotides -800 and -512. 2 consensus sites for the farnesoid X receptor are at nucleotides -473 and -64. The latter is functionally active in bile-acid-mediated feedback of Bsep transcription. PMID: 12135489
    8. Ontogenic changes in bile formation are mediated in part by the regulation of expression of canalicular membrane transporter Bsep. PMID: 12538788
    9. results suggest changes in Bsep localization are involved in estradiol-17beta-D-glucuronide-induced impairment of bile flow and bile salt transport and DBcAMP prevents this effect by stimulating insertion of canalicular transporter-containing vesicles PMID: 12702498
    10. Silibinin prevents bile salt secretory failure by avoiding redistribution of Bsep by a mechanisms involving cyclic AMP and calcium. PMID: 15763547
    11. At least two N-linked glycans are required for ABCB11 protein stability, intracellular trafficking, and function in the apical membrane. PMID: 17082223
    12. In hypoxic liver tissue a marked reduction in the mRNA levels of bile salt export protein was detected before bile duct proliferation occurred. PMID: 17615179
    13. Clinical phenotypes of different types of intrahepatic cholestasis may directly correlate with the amount of mature protein that is expressed at the cell surface. PMID: 17855769
    14. In conclusion, zonal downregulation of Bsep in obstructive cholestasis is associated with portal inflammation and is mediated by TNF-alpha and IL-1beta. PMID: 17916651
    15. Taurocholate transport function was impaired in proportion to rapid degradation of Bsep protein mutants. These results may explain the phenotypic difference between BRIC2 and PFIC2. PMID: 17947449
    16. Hepatic expression of BSEP mRNA decreased after transplantation. PMID: 18551070
    17. Short-chain ubiquitination is associated with the degradation rate of a cell-surface-resident bile salt export pump (BSEP/ABCB11). PMID: 18829893

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  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endosome. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
  • 組織特異性：
    Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
  • 數(shù)據(jù)庫鏈接：


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