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  4. Recombinant Rat Baculoviral IAP repeat-containing protein 5 (Birc5)

Recombinant Rat Baculoviral IAP repeat-containing protein 5 (Birc5)

  • 中文名稱：
    Recombinant Rat Baculoviral IAP repeat-containing protein 5(Birc5)
  • 貨號：
    CSB-YP864316RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Baculoviral IAP repeat-containing protein 5(Birc5)
  • 貨號：
    CSB-EP864316RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Baculoviral IAP repeat-containing protein 5(Birc5)
  • 貨號：
    CSB-EP864316RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Baculoviral IAP repeat-containing protein 5(Birc5)
  • 貨號：
    CSB-BP864316RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Baculoviral IAP repeat-containing protein 5(Birc5)
  • 貨號：
    CSB-MP864316RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Birc5Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-142
  • 氨基酸序列
    MGATALPPIW QMYLKDHRIY TFKNWPFLED CSCTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQVEELTVSE FLKLDKQRAK NKIAKETNNK QKEFEETRRT VRQSIEQLAA LR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Essential for the maintenance of mitochondrial integrity and function.
  • 基因功能參考文獻：
    1. transformed MSCs express high levels of a p53 mutant that loses the ability to bind survivin gene PMID: 27046449
    2. Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer. PMID: 27539959
    3. Birc5 protein PMID: 25856227
    4. NAIP and survivin expressions were significantly reduced following varicocele induction when compared to sham animals whereas PDRN-treated rats showed an increase in NAIP and survivin levels. PMID: 26347229
    5. survivin was significantly downregulated in the rapamycin-treated and rapamycin+Platelet Factor 4-treated group and this was significantly different when compared to controls PMID: 24935577
    6. elevated survivin expression in PBMCs, particularly survivin and CD8, VEGF, and ICAM-1 double-positive PBMCs, may be crucial for good collateral formation in patients with coronary CTO, as confirmed by assessment of a rat model. PMID: 25816072
    7. increased expression of KLF5 may activate p-Survivin expression and play an important role in the pathogenesis of PH in nitrofen-induced CDH. PMID: 25323860
    8. macitentan reversed early but not late obstructive PVD in rats. This reversal was associated with the suppression of survivin-related resistance to apoptosis and proliferation of cells in PVD. PMID: 25539851
    9. No significant differences were found in the promoter region of survivin gene between normal and N-methyl-N-nitrosourea induced colon tumor tissues. PMID: 25318914
    10. IGF-I signaling through a PI3K/Akt/mTORC1 mechanism elevates expression of Survivin and promotes growth of prostate epithelial cells. PMID: 23658701
    11. Survivin over-expression in rat mucin depleted foci indicates that this is an early event in colon carcinogenesis. PMID: 21976248
    12. survivin is involved in regulating the meiotic cell cycle in rat oocytes PMID: 20887644
    13. Survivin is involved in the anti-apoptotic effect of 2-methoxyestradiol treatment, which may up-regulate survivin expression following global ischemia. PMID: 21708067
    14. These data identify survivin as a critical anti-apoptotic regulator of cardiomyocytes after burn injury PMID: 21706383
    15. Survivin, Bcl-2 and p53 may be synergetic in the carcinogenesis of oral cancer. PMID: 19576024
    16. findings indicate that disparate survivin expression levels can explain the discrepancy between gastric epithelial and endothelial cell susceptibility to alcohol-induced injury PMID: 20610854
    17. Survivin expression via PI3K contributes to resistance to cisplatin-induced apoptosis in a rat hepatoma cell line. PMID: 20514400
    18. The HIF-1alpha-survivin pathway appears to facilitate prostate cell survival and growth in zinc-rich environments. PMID: 20564420
    19. Both erythropoitin and methylprednisolone may play important roles in the expression of antiapoptotic survivin and aven genes in heart tissue after traumatic brain injury. [SURVIVIN] PMID: 17112829
    20. Up-regulation of the expressions of survivin and HSP-70 proteins might protect the ischemic brain against reperfusion injury. PMID: 18159002
    21. Survivin is involved in the regulation of acinar cell apoptosis in acute pancreatitis. PMID: 19726343
    22. The over-expression of survivin gene is related to the occurrence of hepatocellular carcinoma. PMID: 18246794
    23. survivin is upregulated by oncogenic c-H-Ras in tumor cells PMID: 12833149
    24. survivin plays an important role in the onset of gastric carcinoma and that high survivin expression is an early event of gastric carcinoma. PMID: 12854136
    25. Results describe BIRC-5/survivin expression throughout the seminiferous epithelial cycle of the rat and its up-regulation by stem cell factor. PMID: 15130521
    26. Survivin may be involved in regulation of neural cell proliferative responses after traumatic brain injury PMID: 15453988
    27. expression of survivin and inducible nitric oxide synthase are early events during malignant transformation and conversion of the oral mucosa PMID: 17428462
    28. survivin may be of importance for renal pathophysiology and pathology PMID: 17982126
    29. Thus, we conclude that primarily survivin and Hsp25/27 may participate in the inhibition of cleaved caspase-3 in reactive astrocytes and may be involved in protecting astrocytes after injury. PMID: 18358624
    30. Survivin is upregulated in human and rodent liver regeneration and correlates with proliferation, suggesting an association of survivin and cell division. PMID: 19018973
    31. ischemic preconditioning inhibits the accumulation of malondialdehyde, advances the expressive phase of survivin protein in hepatic tissue, and improves liver function PMID: 19073407

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Midbody.
  • 蛋白家族：
    IAP family
  • 數據庫鏈接：


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