在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Atrial natriuretic peptide receptor 3 (Npr3), partial

Recombinant Rat Atrial natriuretic peptide receptor 3 (Npr3), partial

In Stock
  • 中文名稱：
    大鼠Npr3重組蛋白
  • 貨號：
    CSB-EP016025RA1
  • 規格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Npr3; Npr-cAtrial natriuretic peptide receptor 3; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor type C; ANP-C; ANPR-C; NPR-C
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Extracellular Domain
  • 來源：
    E.coli
  • 分子量：
    64.9kDa
  • 表達區域：
    41-477aa
  • 氨基酸序列
    EALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
  • 基因功能參考文獻：
    1. These results indicate that C-ANP4-23, via the activation of NPR-C, attenuates Ang II-induced enhanced nitroxidative stress, overexpression of Gialpha proteins, increased activation of the p38/JNK/ERK 1,2 signaling pathways. PMID: 29417337
    2. NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-alpha, which are regulators of apoptosis. PMID: 27494651
    3. down-regulation of Npr3 gene improves the circulatory levels of ANP and antioxidant system and there by attenuates the beta-adrenoceptor over-activation mediated cardiac hypertrophic growth PMID: 27108789
    4. Results from this study point to a role for miR-100 in the regulation of NPR3 expression, and suggest a possible therapeutic target for modulation of NP bioactivity in heart disease. PMID: 25736855
    5. the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP. PMID: 24189506
    6. These results indicate that NPR-C activation by C-ANP4-23 attenuates the enhanced levels of cell cycle proteins through the inhibition of enhanced expression of Gialpha proteins PMID: 24155894
    7. knockdown of NPR-A up-regulates the expression of NPR-C, Gialpha proteins, and NPR-C-linked adenylyl cyclase signalling and suggests a cross-talk between NPR-A and NPR-C. PMID: 22131352
    8. NPR-B mRNA expression was found in both cardiac cells as well as endothelial cells. PMID: 21723350
    9. data presented here suggest that rat NPRC is a substrate for PKA and Thr 505 located within the intracellular domain of NPRC is a likely candidate site for the phosphorylation PMID: 20564198
    10. results demonstrate that NPRs are clearly expressed in the cells located in the ganglion cell layer including the three major subtypes of retinal ganglion cells and the expression is mainly on the membrane of somata PMID: 20304036
    11. The data suggest that in our left ventricular hypertrophy model, the NPR-A and NPR-C receptors were increased in association to the increased BNP level. PMID: 19969282
    12. These data suggest that natriuretic peptides may play a role in maintaining the retinal functions via interaction with NPR-C. PMID: 19878700
    13. Modulation of ANP-C receptor signaling by endothelin-1 in A-10 smooth muscle cells PMID: 12054468
    14. data suggest that C-type natriuretic peptide attenuates neurotransmitter efflux by a mechanism involving suppression of neuronal protein kinase C activity via an interaction with the natriuretic peptide C receptor PMID: 12488334
    15. 17-amino acid sequence (R(469) to R(485)) in the middle region of the intracellular domain of NPR-C is both necessary and sufficient for activation of G proteins and effector enzymes. PMID: 12676657
    16. findings support that ANF exerts a stimulatory effect on pancreatic exocrine secretion mediated by NPR-C receptors coupled to the phosphoinositide pathway PMID: 12829435
    17. participation of NPR-C receptors in C-type natriuretic peptide response PMID: 14599710
    18. a cross-talk between ANP-C receptor-mediated adenylyl cyclase and PLC signaling pathways. PMID: 15044621
    19. Endothelium-derived CNP is involved in the regulation of the coronary circulation, and NPR-C activation underlies the vasorelaxant activity of this peptide. Moreover, this newly defined pathway represents a protective mechanism against I/R injury. PMID: 15337698
    20. The downregulation of ANP and NPRC in retinas of diabetic rats suggests a role for this peptide in experimental diabetic retinopathy. PMID: 15789000
    21. discussion of neuronal regulation and function of natriuretic peptide receptor C [review] PMID: 15911073
    22. Results show that natriuretic peptide receptor NPR-C mediates the activation of nitric oxide synthase by atrial natriuretic peptide in atria. PMID: 16712979
    23. NPRC is a potential direct regulator of pancreatic function. PMID: 17702953
    24. Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. PMID: 17951249
    25. These results suggest that C-ANP(4-23) decreases the enhanced oxidative stress in spontaneously hypertensive rats by attenuating the enhanced expression of Gialpha proteins and also the enhanced levels of NADPH oxidase. PMID: 18162186
    26. our results suggest the existence of a local and complex peptidergic system in the rat testis, involving ANP and its receptors that could importantly modulate the androgen biosynthesis. PMID: 18778744
    27. Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy PMID: 19187227
    28. temporal relationship follows between a NO-induced decreased expression of NPR-C and G(i)alpha proteins PMID: 19252090

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    ANF receptor family
  • 數據庫鏈接：


主站蜘蛛池模板： 99久久久精品免费观看国产| 97国产在线看片免费人成视频| 青青热久免费精品视频| 四川丰满少妇被弄到高潮| 51国产黑色丝袜高跟鞋| 亚洲精品欧美综合四区| 亚洲日韩一中文字暮av| 久久免费看少妇高潮v片特黄| 又黄又爽又无遮挡免费的网站| 中文字幕日韩精品亚洲一区| 东北老女人高潮大喊舒服死了 | 亚洲精品成人片在线播放 | 人人爽人人爽人人片av免费| 丰满的少妇被猛烈进入白浆| 夜夜高潮夜夜爽国产伦精品| 成人性生交大片免费看r老牛网站| 四虎影视无码永久免费| 日本熟妇厨房bbw| 国产人妖xxxx做受视频| 中文字字幕在线中文无码| 中文字幕无码精品亚洲资源网| 中日韩精品视频在线观看| 99久久久国产精品免费蜜臀 | 波多野结衣av在线观看| 国语精品一区二区三区| 人人妻人人爽人人澡欧美一区| 99热网址最新获取域名| 大肉大捧一进一出好爽视色大师| 亚洲精品亚洲人成在线| 凸偷窥中国女人洗澡| 国产99视频精品免费视看6| 无码中文字幕日韩专区视频| 亚洲图片自拍偷图区| 少妇无码精油按摩专区| 亚洲爱婷婷色婷婷五月| 欧美变态另类牲交zozo| 婷婷色香五月综合缴缴情| 色五月丁香六月欧美综合| 日韩中文字幕在线一区二区三区 | 少妇愉情理伦片丰满丰满午夜| 日本丰满熟妇bbxbbxhd|