在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Apelin receptor (Aplnr), partial

Recombinant Rat Apelin receptor (Aplnr), partial

  • 中文名稱：
    Recombinant Rat Apelin receptor(Aplnr),partial
  • 貨號：
    CSB-YP001910RA1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Apelin receptor(Aplnr),partial
  • 貨號：
    CSB-EP001910RA1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Apelin receptor(Aplnr),partial
  • 貨號：
    CSB-EP001910RA1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Apelin receptor(Aplnr),partial
  • 貨號：
    CSB-BP001910RA1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Apelin receptor(Aplnr),partial
  • 貨號：
    CSB-MP001910RA1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Aplnr; Agtrl1; Apj; Apelin receptor; Angiotensin receptor-like 1; B78; G-protein coupled receptor APJ; GPCR34
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone. May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development. Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure.
  • 基因功能參考文獻：
    1. Apelin- induced recovery of ERK1/2 phosphorylation and Kappa Opioid receptors -APJ dimerization may nominate apelin as a therapeutic goal in treatment of renovascular hypertension. PMID: 28987634
    2. Apelin receptor and apelin mRNA were significantly increased in the left ventricle following a high fat diet. PMID: 27378063
    3. APJ mRNA levels were similar in placenta and mesometrial triangle at embryonic day 13. In the placenta, APJ expression was increased at E17 versus the E13 level and reduced at E21, whereas in the Meso-tr an opposite modulation was observed. PMID: 26631739
    4. Apelin receptor mRNA and protein expression in the myocardium and aorta of rats with Goldblatt hypertension. PMID: 25708823
    5. results suggested that static pressure up-regulates APJ expression to promote cardiomyocyte hypertrophy by a PI3K-autophagy pathway PMID: 24966188
    6. Data suggest that apelin receptor has role in regulation of hypothalamic-pituitary-adrenal (HPA) axis response in several models of acute stress and has gender-specific function in peripheral immune activation of HPA axis. PMID: 23086141
    7. Reduction in APJ gene expression during renovascular hypertension in a rat model. PMID: 22796316
    8. APJ exhibits nuclear localization in pulmonary epithelium. PMID: 22015267
    9. These findings bring new insights into apelin receptor activation and show that Phe(255) and Trp(259), by interacting with the C-terminal Phe of the pyroglutamyl form of apelin 13 (pE13F) or K17F, are crucial for apelin receptor internalization. PMID: 20675385
    10. Organ specificity of APJ receptor mRNA and distribution of the APJ receptor in rat brain and spinal cord was determined PMID: 12603839
    11. data verify a role for apelin receptors(APJ) in body fluid regulation PMID: 12787050
    12. Acute and repeated stress exert a stimulatory influence on apelin receptor (APJ receptor, APJR) mRNA expression at the hypothalamic level that may be dependent on basal levels of circulating glucocorticoids. PMID: 14622440
    13. results demonstrate that apelin receptor exhibits nuclear localization in brain, distinct cell-dependent mechanisms for the nuclear transport of apelin receptors, and disruption of nuclear signal sequence disrupts its nuclear translocation PMID: 14645236
    14. APJ exerts the hypotensive effect in vivo and plays a counterregulatory role against the pressor action of angiotensin II PMID: 15087458
    15. Hypoxia increased colonic APJ mRNA levels, and apelin treatment during hypoxia exposure enhanced colonic APJ mRNA levels further. In vitro hypoxia also increased apelin and APJ mRNA levels PMID: 18367654
    16. Rats with cirrhosis treated with the apelin receptor antagonist showed diminished hepatic fibrosis and vessel density, improved cardiovascular performance, and renal function and lost ascites PMID: 18816630

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Widely expressed. Highest expression in the lung, lower in the heart, placenta, ovary, skeletal muscle, mammary gland, kidney and several structures in the brain as the hypothalamus (supraoptic and periventricular nuclei), pituitary, olfactory bulb and pi
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲龙腾成小说人网| 在线观看国产一区二区三区| 亚洲欧美中文日韩在线v日本| 少妇的丰满3中文字幕| 伊人蕉影院久亚洲高清| 亚洲欧美不卡视频在线播放| 国产无遮挡aaa片爽爽 | 中国熟妇牲交视频| 日韩人妻无码精品系列| 99国产欧美另娄久久久精品| 特黄aaaaaaaaa毛片免费视频| 久久se精品一区精品二区| 久久亚洲国产最新网站之一| 国产成人精品手机在线观看| 中文无码乱人伦中文视频在线v| 国产精品久久久久久久久久久久午衣片| 国产情侣疯狂作爱系列| 免费无码午夜理论电影| 中文字幕人妻中文av不卡专区 | 亚洲a成人无m网站在线| 国产午夜人做人免费视频网站| 在线看亚洲十八禁网站| 在线 | 一区二区三区| 四虎影在永久在线观看| 亚洲愉拍二区一区三区| 免费的黄网站在线观看| 久久超碰色中文字幕超清| 2020国产激情视频在线观看| 国产在线国偷精品产拍| 午夜免费视频| 日本欧美一区二区三区高清| 老熟妇乱子伦牲交视频| 欧美国产成人精品一区二区三区| 电影内射视频免费观看| 成年无码动漫av片在线尤物网站| 亚洲精品国产suv一区88| 无码区日韩特区永久免费系列| 夜晚成人18禁区导航网站| 99久久亚洲精品无码毛片| 国产又色又爽又刺激视频| 色老头精品午夜福利视频|